Time-of-flight mass spectrometry (concepts, achievements, and prospects)
Time-of-flight mass spectrometry (concepts, achievements, and prospects)
复制标题
DOI：
10.1016/s1387-3806(00)00392-4
复制
发表时间：
2001-03-22
影响因子：
1.8
通讯作者：
Mamyrin, BA
中科院分区：
文献类型：
--
作者：
Mamyrin, BA
简要介绍了动态质谱仪自问世以来的历史。探讨了上世纪30-40年代发展相对缓慢的原因。指出了所有动态质谱仪操作的一般原理，即质量不同但具有相同能量的离子运动速度之间的差异。根据其标题，该评论更详细地考虑了飞行时间（TOF）质谱仪的发展历史，并强调了它们相对于静态（磁性）仪器的两大优势，即无限的质量范围和在宽离子质量范围内极快速地获得质谱的可能性。这解释了 20 世纪 60 年代至 80 年代期间它们的性能和广泛应用的快速进步，当时人们开始研究重的、热不稳定的有机分子，并开发了产生其离子的有效方法。在制定了TOF质谱仪设计的反射器原理后，TOF仪器分辨率的严重限制在很大程度上被消除。讨论了进一步提高TOF系统分辨率的问题。介绍了 TOF 反射器应用的图示，并指出了分析质量高达数百万道尔顿的分子和团簇的可能性。与磁性装置相比，这些优点导致 TOF 质谱仪的产量急剧增加并扩大了应用潜力，特别是在生物物理学、生物化学和有机化学领域。总之，指出了 TOF 磁共振质谱仪 (MRMS) 在高精度质谱测量领域所开辟的广阔前景。 (Int J Mass Spectrom 206 (1001) 251-266) (C) 2001 Elsevier Science B.V.
A brief account is given of the history of dynamic mass spectrometers from the time of their advent. The reasons fur their relatively slow development in the 1930s-1940s of the last century are discussed. The general principle underlying the operation of all dynamic mass spectrometers, the difference between the velocities of motion of ions differing in mass but having the same energy, is pointed out. In accordance with its title, the review considers in more detail the history of development of time-of-flight (TOF) mass spectrometers and stresses their two major advantages over the static (magnetic) instruments, namely, the unlimited mass range and the possibility of obtaining extremely rapidly mass spectra over a broad ion mass range. This accounts for the fast progress in their performance and broad application in the period of 1960s-1980s, when investigation of heavy, thermally unstable organic molecules was started and efficient methods of producing their ions were developed. A serious limitation on the resolution of TOF instruments was largely removed after the formulation of the reflectron principle of TOF mass-spectrometer design. The problem of a further increase of the resolution of TOF systems is discussed. The illustrations of TOF reflectron applications are presented, and a possibility of analyzing molecules and clusters with masses of up to millions of daltons is pointed out. These merits have resulted in a sharp increase of production and a broadening of application potential of TOF mass spectrometers compared to the magnetic setups, particularly in the field of biophysics, biochemistry, and organic chemistry. In conclusion the broad horizons opened by the TOF magnetic-resonance mass spectrometers (MRMS) in the area of high-precision mass spectrometric measurements are pointed out. (Int J Mass Spectrom 206 (1001) 251-266) (C) 2001 Elsevier Science B.V.