Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease.
Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease.
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与阿尔茨海默氏病皮质-皮质下功能障碍相关的精神症状。
DOI：
10.1176/jnp.13.1.56
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
DeKosky,ST
中科院分区：
文献类型：
--
作者：
Lopez,OL;Zivkovic,S;Smith,G;Becker,JT;Meltzer,CC;DeKosky,ST
应用正电子发射断层扫描技术对3例阿尔茨海默病（AD）患者进行了评估：1例伴重度抑郁，1例伴情绪不稳定，1例伴冷漠。与5名非情绪障碍的AD患者相比，抑郁症患者双侧前扣带回和上级颞叶皮质的相对局部脑血流量（rel-CBF）减少。该患者还显示左侧背外侧前额叶和右侧内侧颞叶和顶叶皮质的rel-CBF减少。情绪不稳定的患者双侧前扣带回和背外侧前额叶皮质以及左侧基底神经节的rel-CBF减少。情感淡漠的患者双侧基底节和背外侧前额叶皮层的rel-CBF减少。结果与共同的额颞皮质下基底的假设一致（例如，涉及胺能核）在AD抑郁症病因学中的作用。额皮质下功能障碍也可能与AD患者的情绪不稳定和冷漠有关，尽管这些可能与额基底神经节回路的更多参与有关。
Positron emission tomography was used to evaluate 3 Alzheimer's disease (AD) patients: 1 with major depression, 1 with emotional lability, and 1 with apathy. Compared with 5 non–mood-disordered AD patients, the patient with depression had diminished relative regional cerebral blood flow (rel-CBF) in the anterior cingulate and superior temporal cortices, bilaterally. This patient also showed diminished rel-CBF in the left dorsolateral prefrontal and right medial temporal and parietal cortices. The patient with emotional lability had diminished rel-CBF in the anterior cingulate and dorsolateral prefrontal cortices, bilaterally, and left basal ganglia. The patient with apathy had diminished rel-CBF in the basal ganglia and dorsolateral prefrontal cortex, bilaterally. Results are consistent with the hypothesis of a common frontal-temporal-subcortical substrate (e.g., involving aminergic nuclei) in the etiology of depression in AD. Frontal-subcortical dysfunction may also be associated with emotional lability and apathy in AD, although these may be related to a greater involvement of frontal–basal ganglia circuits.