Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases.
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases.
复制标题
肺部发育和炎症性肺部疾病中的胰岛素样生长因子-1 信号传导
DOI：
10.1155/2018/6057589
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发表时间：
2018
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang Z;Li W;Guo Q;Wang Y;Ma L;Zhang X
胰岛素样生长因子-1（IGF-1）是最早发现的一种介导生长激素生物学效应的激素。越来越多的数据表明IGF-1信号通路在肺发育和疾病如先天性疾病、癌症、炎症和纤维化中的作用。IGF-1信号调节许多类型的肺细胞的发育和分化，包括气道基底细胞、俱乐部细胞、肺泡上皮细胞和成纤维细胞。IGF-1信号传导缺陷导致人类肺泡增生和动物模型中的肺结构破坏。IGF-1信号通路的组分被强化为生物标志物，因为它们在肺部疾病中局部或全身失调，而不同研究之间的数据可能不一致甚至矛盾。基于IGF-1的治疗剂的使用促使对发育障碍和炎性肺病进行更多的研究，因为目前的大多数数据是从有限数量的动物实验中收集的，并且通常不如肺癌中的数据丰富。这些问题的阐明，通过进一步的实验室到床边的研究可能会为我们提供合理的临床诊断方法和药物IGF-1信号在肺部疾病。
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.
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影响因子：
8.8
作者：
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通讯作者：
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4.8
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5
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影响因子：
3.7
作者：
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通讯作者：
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