Risk Factors for Impaired Instrumental Activities of Daily Living in Alzheimer's Disease
Risk Factors for Impaired Instrumental Activities of Daily Living in Alzheimer's Disease
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阿尔茨海默病患者日常生活工具性活动受损的危险因素
DOI：
10.11596/asiajot.14.9
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Daisuke Kimura
中科院分区：
文献类型：
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作者：
Takashi Fujita;Masako Notoya;Nobuyuki Sunahara;Ken Nakatani;Daisuke Kimura
目的：尽管对生活在家中的痴呆患者维持工具性日常生活活动（IADL）的支持相当重要，但还没有正式的调查研究影响IADL的因素。方法：我们进行了各种神经心理学测试，定时起身和行动测试（TUG），和老年抑郁症筛查量表-15至54名日本人，他们去过日托中心或预防护理班，轻度AD）或31例无痴呆。结果：与弗伦谢活动指数中家务事分量表相关的因素有性别、Wechsler记忆量表（WMS-R）和TUG测验成绩（R2 = 0.53）。休闲/工作分量表的相关因素是WMS-R上的向后数字回忆和逻辑记忆II表现，执行障碍综合征的行为评估得分和TUG测试表现（R2 = 0.66）。最后，与户外分量表相关的因素有向后数字回忆、逻辑记忆II和TUG测试成绩（R2 = 0.6 2）。结论：轻度AD或非痴呆老年人IADL的影响因素因IADL类型而异。值得注意的是，TUG测试表现对所有IADL类型都有直接影响，并且可能与认知功能有关。当提供预防性护理或IADL支持时，评估和干预可能是有益的，重点是本研究中强调的认知和身体功能。
Objective: Despite the considerable importance of maintaining support for instrumental activities of daily living (IADLs) for patients with dementia living at home, there have been no formal investigations of what factors influence IADLs.Method: We administered various neuropsychological tests, the Timed Up and Go [TUG] test, and the Geriatric Depression Screening Scale-15 to 54 individuals in Japan who had visited a day care center or a preventative care class and who had either 23 mild Alzheimer's disease (mild AD) or 31 no dementia. IADLs were measured using the Self-Report Frenchay Activities Index.Results: The factors related to the domestic chores subscale of the Frenchay Activities Index were gender, backward digit recall performance (Wechsler Memory Scale-Revised [WMS-R]), and TUG test performance (R 2= 0.53). Factors related to the leisure/work subscale were backward digit recall and logical memory II performance on the WMS-R, scores on the Behavioral Assessment of the Dysexecutive Syndrome, and TUG test performance (R 2= 0.66). Finally, factors related to the outdoor subscale were backward digit recall, logical memory II, and the TUG test performance (R 2= 0.62).Conclusions: The factors affecting IADLs among elderly individuals with mild AD or no dementia vary depending on the type of IADL. Notably, TUG test performance has a direct influence on all IADL types, and might relate to cognitive function. When providing preventative care or IADL support, it may be beneficial to evaluate and intervene with a focus on the cognitive and physical functions highlighted in this study.