Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
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DOI：
10.1086/591913
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发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Corey, Lawrence
中科院分区：
文献类型：
--
作者：
Mark, Karen E.;Wald, Anna;Corey, Lawrence
背景单纯疱疹病毒（HSV）潜伏在感染者的神经根神经节中，每年会重新激活数次。最近的原位数据显示HSV特异性CD 8（+）T细胞定位于邻近外周感觉神经末梢的真皮表皮交界处，这表明病毒再激活可能比以前认识的更频繁地发生。25名HSV-2血清阳性和18名HSV-1血清阳性健康成人分别采集肛门生殖器和口腔拭子，每天4次，持续60天。用定量聚合酶链反应检测拭子中的HSV。24%的肛门生殖器再激活和21%的口腔再激活持续时间
Background. Herpes simplex virus (HSV) remains latent in nerve root ganglia of infected persons and is thought to reactivate several times yearly. Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated.Methods. Twenty-five HSV-2-seropositive and 18 HSV-1-seropositive healthy adults collected anogenital and oral swabs, respectively, 4 times per day for 60 days. Swabs were assayed for HSV, using a quantitative polymerase chain reaction assay.Results. Twenty-four percent of anogenital reactivations and 21% of oral reactivations lasted