Emotional memory and psychopathology
Emotional memory and psychopathology
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DOI：
10.1098/rstb.1997.0154
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发表时间：
1997-11-29
期刊：
影响因子：
--
通讯作者：
Muller, J
中科院分区：
文献类型：
--
作者：
Ledoux, JE;Muller, J
研究大脑如何储存关于不愉快经历的记忆的一个领先模型是恐惧条件反射。一系列累积的工作已经确定了调节这种学习形式的神经系统的主要组成部分。这些通路涉及将感觉信息从丘脑和皮质的加工区传输到杏仁核。杏仁核的外侧核接收并整合来自丘脑和皮质区域的感觉输入，中央核提供与以各种方式(行为、自主神经、内分泌)控制特定恐惧反应的运动系统的接口。杏仁核内的内部连接允许外侧核和中央核进行通信。最近的研究已经开始确定一些可塑性部位的电路和细胞机制涉及恐惧条件反射。通过对恐惧条件作用的研究，我们对情绪记忆的理解被带到了大脑细胞和突触的水平上。在理解情绪记忆方面的进展为情绪障碍提供了更好的定义和治疗方法的可能性。
A leading model for studying how the brain farms memories about unpleasant experiences is fear conditioning. A cumulative body of work has identified major components of the neural system mediating this form of learning. The pathways involve transmission of sensory information from processing areas in the thalamus and cortex to the amygdala. The amygdala's lateral nucleus receives and integrates the sensory inputs from the thalamic and cortical areas, and the central nucleus provides the interface with motor systems controlling specific fear responses in various modalities (behavioural, autonomic, endocrine). Internal connections within the amygdala allow the lateral and central nuclei to communicate. Recent studies have begun to identify some sites of plasticity in the circuitry and the cellular mechanisms involved in fear conditioning. Through studies of fear conditioning, our understanding of emotional memory is being taken to the level of cells and synapses in the brain. Advances in understanding emotional memory hold out the possibility that emotional disorders may be better defined and treatment improved.