Modeling the Effects of Hypoglycemia on a Two-Choice Task in Adult Humans
Modeling the Effects of Hypoglycemia on a Two-Choice Task in Adult Humans
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DOI：
10.1037/a0020074
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发表时间：
2010-09-01
期刊：
影响因子：
2.4
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Geddes, Jacqueline;Ratcliff, Roger;Deary, Ian J.
目的：先前的研究表明，低血糖会导致反应时间变慢且变化更大。然而，反应时间测试使用多种认知和非认知过程。这项研究首次使用经过验证的顺序抽样模型（扩散模型）应用于成年人的简单二选一任务获得的结果，以评估低血糖对决策基本参数的影响。方法：十四名成年志愿者在血糖浓度降低和不降低的情况下接受了数字辨别任务的测试。使用模型对结果进行分析，该模型剖析了决策过程中的各个组成部分：决策所依据的信息的质量（漂移率）、做出决策之前必须积累的关键证据量（边界分离）。以及非决策过程所花费的时间。结果：低血糖导致平均漂移率从 0.290 降低至 0.211，t(13) = 4.10，p < .05。没有观察到实验状态对做出决定或外围和运动过程所需的证据量的影响。结论：本研究定位了与低血糖相关的精确处理缺陷，并进一步了解低血糖的精确认知效应。需要进一步研究改善这些影响。
Objective: Previous research has demonstrated that hypoglycemia causes reaction times to be slower and more variable. Reaction time tests, however, use multiple cognitive and noncognitive processes. This study is the first to use a validated sequential sampling model (diffusion model) applied to results obtained from a simple 2-choice task in adult humans to assess the effects of hypoglycemia on the basic parameters of decision making. Method: Fourteen adult volunteers were tested on a numerosity discrimination task with and without reduced blood glucose concentrations. The results were analyzed with a model that dissects the components of processing that underlie decisions: the quality of the information on which a decision is based (drift rate), the critical amount of evidence that must be accumulated before a decision is made (boundary separation). and the time taken by nondecision processes. Results: Hypoglycemia resulted in a reduction of mean drift rate from 0.290 to 0.211, t(13) = 4.10, p < .05. No effect of experimental state was observed on the amount of evidence required to make a decision or peripheral and motor processes. Conclusion: This study locates the precise processing deficit associated with hypoglycemia and provides further understanding of the precise cognitive effect of hypoglycemia. Further research into the amelioration of these effects is required.