Cocarcinogenic Action of Aspirin on Gastric Tumors Induced by N-Nitroso-N-methylnitroguanidine in Rats1
Cocarcinogenic Action of Aspirin on Gastric Tumors Induced by N-Nitroso-N-methylnitroguanidine in Rats1
复制标题
阿司匹林对N-亚硝基-N-甲基硝基胍诱发的大鼠胃肿瘤的致癌作用1
DOI：
10.1093/jnci/70.6.1067
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Chang Yee
中科院分区：
文献类型：
--
作者：
Chang Tsung;L. Yu;Lee Kwang;Sun Cheng;Chang Yee
将白化病大鼠（非近交系）分为4组：对照组56只，阿司匹林混悬液（40 mg/ml）组40只，N-亚硝基-N-甲基硝基胍（MNNG）溶液（250 μ g/ml）组20只，阿司匹林+MNNG组40只。18个月内，第1组和第2组无胃肠道肿瘤，第3组有8例胃肿瘤，第4组有37例胃肿瘤。第4组40只大鼠中有21只发现腺胃腺癌，而第3组20只大鼠中仅4只发现腺胃腺癌;发生率差异显著。第4组表皮样癌和腺癌的组织学和电镜检查显示与仅用MNNG诱导的此类肿瘤无差异。第4组腺胃的前胃粘膜增生和幽门腺区增生较重。
Albino rats (noninbred) were divided into 4 groups: 1) 56 control rats, 2) 40 rats fed 1 ml aspirin suspension (40 mg/ml) twice a week, 3) 20 rats given N-nitroso-N-methylnitroguanidine (MNNG) solution (250 micrograms/ml) to drink ad libitum, and 4) 40 rats given both aspirin and MNNG. In 18 months, there were no gastrointestinal tumors in groups 1 and 2, 8 cases of gastric tumors in group 3, and 37 cases of gastric tumors in group 4. Adenocarcinomas of the glandular stomach were found in 21 of 40 rats in group 4 but in only 4 of the 20 rats in group 3; the difference in incidence was significant. Histologic and electron microscopic examination of the epidermoid carcinomas and adenocarcinomas in group 4 showed no difference from such tumors induced by MNNG only. Hyperplasia of the forestomach mucosa and hyperplasia of the pyloric gland region of the glandular stomach in group 4 were more severe.