Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL
Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL
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DOI：
10.1016/j.intimp.2004.05.011
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发表时间：
2004-09-01
影响因子：
5.6
通讯作者：
Nasu, M
中科院分区：
文献类型：
--
作者：
Mizunoe, S;Kadota, J;Nasu, M
为了评价大环内酯类抗生素的抗炎作用，我们研究了大环内酯类抗生素是否能诱导活化的淋巴细胞凋亡。与对照组相比，克拉霉素和阿奇霉素可增加凋亡细胞的比例。Fas和Fas配体的表达在对照组和大环内酯治疗组之间没有显著差异。与对照组相比，黄芪和黄芪提取物均抑制Bcl-xL的表达。我们的结果表明，CLR和AXM通过下调Bcl-xL来增强活化淋巴细胞的凋亡。(C)2004 Elsevier B. V.保留所有权利。
To evaluate the anti-inflammatory action of macrolide antibiotics, we examined whether macrolide antibiotics could induce apoptosis of activated lymphocytes. The proportion of apoptotic cells was augmented by clarithromycin (CLR) and azithromycin (AZM) compared with control. There was no significant difference in Fas and Fas-ligand expression between the control and macrolide-treated groups. CLR and AZM inhibited the expression of Bcl-xL compared with that of control. Our results suggest that CLR and AZM enhance apoptosis of activated lymphocytes by down-regulation of Bcl-xL. (C) 2004 Elsevier B.V. All rights reserved.