Viroids and RNA silencing: mechanism, role in viroid pathogenicity and development of viroid-resistant plants.
Viroids and RNA silencing: mechanism, role in viroid pathogenicity and development of viroid-resistant plants.
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DOI：
10.4161/gmcr.1.2.11871
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Hadidi, Ahmed
中科院分区：
文献类型：
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作者：
Sano, Teruo;Barba, Marina;Hadidi, Ahmed
类病毒是自主复制的小型单链环状RNA病原体，不编码蛋白质，可能在受感染的易感植物中引起疾病。它们有能力在受感染植物中诱导RNA介导的转录基因沉默（TGS）和转录后基因沉默（PTGS），或RNA沉默。它们诱导的RNA沉默也已在小麦胚芽提取物系统中得到证实。讨论了RNA沉默在类病毒致病性和进化中的可能作用。有人建议，RNA沉默可以用于工程植物的类病毒抗性，并尝试生产这些植物也进行了讨论。
Viroids are autonomously replicating, small single-stranded circular RNA pathogens that do not code for proteins and may cause diseases in infected, susceptible plants. They have the ability to induce both RNA-mediated transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS), or RNA silencing, in infected plants. Their induced RNA silencing has also been demonstrated in a wheat germ extract system. A possible role of RNA silencing in viroid pathogenicity and evolution has been discussed. It is suggested that RNA silencing can be employed to engineer plants for viroid resistance and attempts to produce these plants have been also discussed.