Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging - comparison with positron emission tomography
Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging - comparison with positron emission tomography
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DOI：
10.1038/sj.jcbfm.9600187
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发表时间：
2006-02-01
影响因子：
6.3
通讯作者：
Ohno, K
中科院分区：
文献类型：
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作者：
Tanaka, Y;Nariai, T;Ohno, K
我们研究了慢性闭塞性脑血管病患者的血流动力学应激程度是否可以用灌注加权磁共振成像（PWI）进行定量评估。36例烟雾病患者（平均年龄26.8岁，范围18 ~ 59岁）在一个月内接受了PWI和正电子发射断层扫描（PET）。PWI数据通过三种不同的分析方法计算。以小脑为对照区，计算前循环的脑血流量（CBF）比、脑血容量（CBV）比和平均通过时间（MTT），并与PET数据进行比较。PWI参数图的分辨率比PET图更高，并在逐脑回水平上显示局灶性灌注失败。PWI获得的相对CBV和MTT与相应的PET值呈显著线性相关（CBV，R-2 = 0.47至0.58; MTT，R-2 = 0.32至0.68）。我们还发现，我们可以检测区域异常升高的OEF和CBV的基础上的延迟PWI测量MTT相对于控制区域定义为2.0秒的延迟作为阈值。对OEF异常升高区域的敏感性和特异性分别为92.3%和100%，对CBV异常升高区域的敏感性和特异性分别为20.0%和100%。在PWI获得的参数中，我们的结果表明，相对CBV值和MTT延迟可以定量操作，以协助烟雾病患者的临床决策。
We examined whether the degree of hemodynamic stress in patients with chronic occlusive cerebral vascular disease can be quantitatively evaluated with the use of perfusion-weighted magnetic resonance imaging (PWI). Thirty-six patients with moyamoya disease ( mean age, 26.8 years; range, 18 to 59) underwent PWI and positron emission tomography ( PET) within a month's interval. The PWI data were calculated by three different analytic methods. The cerebral blood flow (CBF) ratio, cerebral blood volume (CBV) ratio, and mean transit time (MTT) of the anterior circulation were calculated using the cerebellum as a control region and compared with PET data on the same three parameters and oxygen extraction fraction (OEF). Parametric maps of PWI attained a higher resolution than the PET maps and revealed focal perfusion failure on a gyrus-by-gyrus level. The relative CBV and MTT obtained with PWI showed significant linear correlations with the corresponding PET values ( CBV, R-2 = 0.47 to 0.58; MTT, R-2 = 0.32 to 0.68). We also found that we could detect regions with abnormally elevated OEF and CBV based on the delay of PWI-measured MTT relative to the control region by defining a 2.0-sec delay as a threshold. The sensitivity and specificity were 92.3% and 100% in detecting regions with abnormally elevated OEF, and 20.0% and 100% in detecting regions with abnormally elevated CBV, respectively. Among the parameters obtained with PWI, our results suggested that the relative CBV value and delay of MTT might be quantitatively manipulated to assist in clinical decision-making for patients with moyamoya disease.