Coordinated multiplexing of information about separate objects in visual cortex.
Coordinated multiplexing of information about separate objects in visual cortex.
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DOI：
10.7554/elife.76452
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发表时间：
2022-11-29
期刊：
影响因子：
7.7
通讯作者：
Groh JM
中科院分区：
文献类型：
--
作者：
Jun NY;Ruff DA;Kramer LE;Bowes B;Tokdar ST;Cohen MR;Groh JM
感觉感受野足够大，它们可以包含不止一个可感知的刺激。那么，大脑如何对特定时刻可能出现的每一种刺激的信息进行编码呢？我们最近发现，当存在不止一个刺激时，单个神经元可以在一段时间内在编码一个与另一个之间波动(S)，这表明不同刺激的神经复用形式(Caruso等人，2018年)。在这里，我们调查(A)这种编码波动是否发生在早期的视觉皮质区域；(B)编码波动是如何在神经群体中协调的；以及(C)协调编码波动如何依赖于将刺激解析为单独的与融合的对象。我们发现，猕猴V1的编码波动确实会发生，但只有在两个刺激形成单独的对象时才会发生。这些独立的物体唤起了一种新的V1峰计数(噪声)相关性模式，涉及正值和负值的不同分布。这种双峰相关模式在成对的神经元中最明显，显示出编码波动或多路传输的最有力证据。一对给定的神经元是否表现出正相关或负相关，取决于这两个神经元对同一对象的反应是更好还是有不同的对象偏好。基于刺激偏好的棘波计数相关性的不同分布在V4中也可以看到，但当两个刺激融合成一个对象时，就看不到了。这些发现表明，多个物体引起的反应动力学不同于由单一刺激引起的反应动力学，这支持了多路传输假说，并提出了一种方法，通过这种方法，尽管感觉编码明显粗糙，但关于多个物体的信息可以被保存下来。
Sensory receptive fields are large enough that they can contain more than one perceptible stimulus. How, then, can the brain encode information about each of the stimuli that may be present at a given moment? We recently showed that when more than one stimulus is present, single neurons can fluctuate between coding one vs. the other(s) across some time period, suggesting a form of neural multiplexing of different stimuli (Caruso et al., 2018). Here, we investigate (a) whether such coding fluctuations occur in early visual cortical areas; (b) how coding fluctuations are coordinated across the neural population; and (c) how coordinated coding fluctuations depend on the parsing of stimuli into separate vs. fused objects. We found coding fluctuations do occur in macaque V1 but only when the two stimuli form separate objects. Such separate objects evoked a novel pattern of V1 spike count (‘noise’) correlations involving distinct distributions of positive and negative values. This bimodal correlation pattern was most pronounced among pairs of neurons showing the strongest evidence for coding fluctuations or multiplexing. Whether a given pair of neurons exhibited positive or negative correlations depended on whether the two neurons both responded better to the same object or had different object preferences. Distinct distributions of spike count correlations based on stimulus preferences were also seen in V4 for separate objects but not when two stimuli fused to form one object. These findings suggest multiple objects evoke different response dynamics than those evoked by single stimuli, lending support to the multiplexing hypothesis and suggesting a means by which information about multiple objects can be preserved despite the apparent coarseness of sensory coding.
影响因子：
3.4
作者：
Willett, Shawn M.;Groh, Jennifer M.
通讯作者：
Groh, Jennifer M.
影响因子：
3.7
作者：
Lehky, Sidney R.;Peng, Xinmiao;McAdams, Carrie J.;Sereno, Anne B.
通讯作者：
Sereno, Anne B.