Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm
Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm
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DOI：
10.1677/joe-07-0376
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发表时间：
2008-05-01
影响因子：
4
通讯作者：
Genazzani, Andrea R.
中科院分区：
文献类型：
--
作者：
Begliuomini, Silvia;Lenzi, Elena;Genazzani, Andrea R.
包括脑源性神经营养因子（BDNF）在内的神经营养因子的表达和分泌也受神经元活动的调节。文献中可获得的数据表明，BDNF中枢水平受光和暗的影响。在大鼠中枢神经系统中，BDNF mRNA和蛋白质含量的昼夜变化已被证实。基于这些证据，我们研究了人类男性BDNF循环水平可能存在昼夜变化的假设。此外，我们寻找与皮质醇昼夜节律的可能相关性，因为BDNF和皮质醇都与大脑功能的维持有关。在这项研究中，34名健康的年轻男性志愿者。每名受试者每月定期采集3次血液样本（0800、1200、1600、2000和2400 h）。在所有样本中测量了脑源性神经营养因子和皮质醇。用ELISA法测定BDNF的含量。我们的研究结果表明，血浆BDNF水平，以及皮质醇水平，在早上比晚上显著升高（P
Expression and secretion of neurotrophins, including brain-derived neurotrophic factor (BDNF), are regulated also by neuronal activity Data available in the literature suggest that BDNF central levels are influenced by light and dark. Diurnal changes of BDNF mRNA and protein contents have been demonstrated in the rat central nervous system. Based on these pieces of evidence, we investigated the hypothesis of a possible diurnal variation of BDNF circulating levels in human males. Moreover, we looked for a possible correlation with cortisol circadian rhythm, since both BDNF and cortisol are implicated in the maintenance of cerebral functions. In this study, 34 healthy young male volunteers were included. Five blood samples were drawn from each subject thrice in a month at regular 4-h intervals (0800, 1200, 1600, 2000, and 2400 h). BDNF and cortisol were measured in all samples. BDNF was determined by ELISA method. Our results show that plasma BDNF levels, as well as cortisol levels, are significantly higher in the morning when compared with the night (P