A few thoughts on brain ROIs.

A few thoughts on brain ROIs.
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DOI:
10.1007/s11682-011-9123-6
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发表时间:
2011-09
影响因子:
3.2
通讯作者:
Liu, Tianming
Liu, Tianming
中科院分区:
医学3区
文献类型:
--
作者:
Liu, Tianming

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通过非侵入性神经成像对人脑的结构和功能连接进行定量映射,为了解大脑结构提供了一个令人兴奋和独特的机会。由于连接性改变在各种脑部疾病中被广泛报道,因此结构和功能连接性的评估已成为临床神经科学的基础研究领域。当试图映射结构和功能连接时,一个基本的问题出现了:如何定义和定位最好的感兴趣区域(ROI)用于大脑连接映射?从本质上讲,在绘制大脑连接图时,ROI为测量个体大脑内的连接性和跨人群汇集数据提供了结构基础。因此,识别可靠的,可重复的和准确的ROI对于脑连接映射的成功至关重要。本文从我们的角度讨论了定义最佳大脑ROI的几个主要挑战,并根据我们小组最近的研究工作提出了一些关于如何应对这些挑战的想法。
Quantitative mapping of structural and functional connectivities in the human brain via non-invasive neuroimaging offers an exciting and unique opportunity to understand brain architecture. Because connectivity alterations are widely reported in a variety of brain diseases, assessment of structural and functional connectivities has emerged as a fundamental research area in clinical neuroscience. A fundamental question arises when attempting to map structural and functional connectivities: how to define and localize the best possible Regions of Interests (ROIs) for brain connectivity mapping? Essentially, when mapping brain connectivities, ROIs provide the structural substrates for measuring connectivities within individual brains and for pooling data across populations. Thus, identification of reliable, reproducible and accurate ROIs is critically important for the success of brain connectivity mapping. This paper discusses several major challenges in defining optimal brain ROIs from our perspective and presents a few thoughts on how to deal with those challenges based on recent research work done in our group.
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