Hyper-viscoelastic damage modeling of whole blood clot under large deformation
Hyper-viscoelastic damage modeling of whole blood clot under large deformation
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DOI：
10.1007/s10237-021-01467-z
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发表时间：
2021-06-02
影响因子：
3.5
通讯作者：
Dortdivanlioglu, Berkin
中科院分区：
文献类型：
--
作者：
Rausch, Manuel K.;Sugerman, Gabriella P.;Dortdivanlioglu, Berkin
血凝块在我们的身体中发挥着直接的作用，因为它们既是至关重要的伤口密封剂，也是许多毁灭性疾病的根源。在血凝块的生理和病理作用中，其力学起着关键作用。由于血凝块复杂的非线性粘弹性行为，这些力学是不平凡的。将这种行为转化为数学形式是对血凝块更好的基础科学理解以及诊断和预后计算模型的基础步骤。在这里，我们确定了一个超粘弹性损伤模型，我们适合的非线性，血液凝块的粘弹性行为的原始数据。我们的模型结合了经典的奥格登超弹性本构律，有限的粘弹性模型的大变形，和非局部的，梯度增强损伤制定。通过将我们的模型拟合到循环拉伸试验数据和失效延伸率数据，我们告知了模型的九个未知材料参数。我们通过针对未见过的循环拉伸测试和应力松弛数据进行验证，证明了我们模型的可预测性。我们的原始数据，模型配方，并确定本模型的本构参数是公开提供给其他人使用，这将有助于开发准确的，定量的血液凝块力学模拟。
Blood clots play a diametric role in our bodies as they are both vital as a wound sealant, as well as the source for many devastating diseases. In blood clots' physiological and pathological roles, their mechanics play a critical part. These mechanics are non-trivial owing to blood clots' complex nonlinear, viscoelastic behavior. Casting this behavior into mathematical form is a fundamental step toward a better basic scientific understanding of blood clots, as well as toward diagnostic and prognostic computational models. Here, we identify a hyper-viscoelastic damage model that we fit to original data on the nonlinear, viscoelastic behavior of blood clots. Our model combines the classic Ogden hyperelastic constitutive law, a finite viscoelastic model for large deformations, and a non-local, gradient-enhanced damage formulation. By fitting our model to cyclic tensile test data and extension-to-failure data, we inform the model's nine unknown material parameters. We demonstrate the predictability of our model by validating it against unseen cyclic tensile test and stress-relaxation data. Our original data, model formulation, and the identified constitutive parameters of this model are openly available for others to use, which will aid in developing accurate, quantitative simulations of blood clot mechanics.