Peripartum hypoxic risk and cognitive outcome: a study of term and preterm birth children at early school age.
Peripartum hypoxic risk and cognitive outcome: a study of term and preterm birth children at early school age.
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DOI：
10.1037//0894-4105.13.4.598
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发表时间：
1999-10
期刊：
影响因子：
2.4
通讯作者：
C. P. Stevens;S. Raz;C. Sander
中科院分区：
文献类型：
--
作者：
C. P. Stevens;S. Raz;C. Sander
作者研究了早期学龄儿童的妊娠成熟度、围产期缺氧风险和智力结果之间的关系。样本包括48名儿童，他们在分娩后3小时内测得的动脉pH值介于7.3(正常范围的下限)至7.1(中度酸中毒范围的下限)之间。妊娠成熟度并不能解释结局差异的显著比例，而动脉血pH值被发现与随后的智力表现显著相关。观察到的围产期动脉pH与认知能力之间的关系尤其值得注意，因为动脉pH范围受到限制。作者得出结论，即使酸度范围的下限被截断到被认为反映新生儿严重窒息的pH值水平以上，在早期学龄儿童的动脉pH和智力结果之间也可以观察到一种“剂量-反应”关系。
The authors examined the relationships between gestational maturity, perinatal hypoxic risk, and intellectual outcome in early school-age children. The sample was composed of 48 children whose arterial pH obtained within 3 hr after delivery was between 7.3 (the lower end of the normal range) and 7.1 (the lower end of the moderately acidotic range). Gestational maturity did not account for a significant proportion of variance in outcome, whereas arterial pH was found to be significantly related to subsequent intellectual performance. The observed relationship between peripartum arterial pH and cognitive performance is especially noteworthy because the arterial pH range was restricted. The authors conclude that a "dose-response" relationship can be observed between arterial pH and intellectual outcome at early school age, even when the lower end of the acidotic range is truncated above the pH level that is thought to reflect severe asphyxia neonatorum.