Notch in mammary gland development and breast cancer
Notch in mammary gland development and breast cancer
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DOI：
10.1016/j.semcancer.2004.04.013
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发表时间：
2004-10-01
影响因子：
14.5
通讯作者：
Kitajewski, J
中科院分区：
文献类型：
--
作者：
Politi, K;Feirt, N;Kitajewski, J
Notch信号转导参与了许多过程，包括细胞命运决定和肿瘤发生。在小鼠中，Notch1和Notch4基因都是小鼠乳腺肿瘤病毒插入和重排的靶基因，这些突变促进上皮乳腺肿瘤发生。此外，Notch4的组成型活性形式在乳腺上皮细胞中的表达抑制上皮分化并导致该器官中的肿瘤形成。这些数据暗示Notch通路在乳腺肿瘤发生中的作用，并为未来的实验提供基础，这将有助于我们了解Notch在人类乳腺癌发展中的作用。在这里，我们回顾了Notch在小鼠和体外培养模型中诱导乳腺肿瘤发生的研究，提供证据表明Notch激活是人类乳腺癌的致病因素（C）2004 Elsevier Ltd.保留所有权利。
Notch signaling has been implicated in many processes including cell fate determination and oncogenesis. In mice, the Notch1 and Notch4 genes are both targets for insertion and rearrangement by the mouse mammary tumor virus and these mutations promote epithelial mammary tumorigenesis. Moreover, expression of a constitutively active form of Notch4 in mammary epithelial cells inhibits epithelial differentiation and leads to tumor formation in this organ. These data implicate the Notch pathway in breast tumorigenesis and provide the foundation for future experiments that will aid in our understanding of the role of Notch in human breast cancer development. Here, we review studies of mammary tumorigenesis induced by Notch in mouse and in vitro culture models providing evidence that Notch activation is a causal factor in human breast cancer (C) 2004 Elsevier Ltd. All rights reserved.