Synergy between human monoclonal antibodies to HIV extends their effective biologic activity against homologous and divergent strains.
Synergy between human monoclonal antibodies to HIV extends their effective biologic activity against homologous and divergent strains.
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人类 HIV 单克隆抗体之间的协同作用扩展了它们针对同源和不同菌株的有效生物活性。
DOI：
10.1089/aid.1992.8.425
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发表时间：
1992
影响因子：
1.5
通讯作者：
Zolla-Pazner,S
中科院分区：
文献类型：
--
作者：
Buchbinder,A;Karwowska,S;Gorny,MK;Burda,ST;Zolla-Pazner,S
致编辑：被动免疫已被用于预防和治疗许多细菌和病毒性疾病'2，并且已被证明可以预防黑猩猩感染 HIV-1.3'4 鉴于这些先例，^ 被动免疫疗法可能有助于 (a) 预防意外接触后医护人员感染 HIV，(b) 阻止 HIV 从受感染母亲传播给胎儿，以及 (c) 治疗既往感染 HIV 的患者。在所有这些情况下，最佳治疗似乎是使用免疫球蛋白制剂，该制剂可以肌肉注射，并且可以中和大多数（如果不是全部）HIV-1 病毒株。一种或多种人单克隆抗体 (MAb) 的制剂有可能满足所有这些标准。
To the Editor: Passive immunization has been used to prevent and treat many bacterial and viral illnesses', 2 and has been shown to prevent the infection of chimpanzees with HIV-1.3'4 Given these prece¬ dents,^ is likely that passive immunotherapy may be useful in (a) preventing HIV infection in health care workers after acci¬ dental exposure,(b) blocking transmission of HIV from the infected mother to her fetus, and (c) treating previously HIV-infected patients. In all of these instances, the optimal treatment would seem to be with an immunoglobulin preparation which can be administered intramuscularly and which would neutralize a majority, if not all, HIV-1 strains. A preparation of one or several human monoclonal antibodies (MAbs) could potentially meet all of these criteria.