Lipids in cancer — a functional or a fictional association?
Lipids in cancer — a functional or a fictional association?
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癌症中的脂质——功能性关联还是虚构关联？
DOI：
10.1016/0968-0004(83)90346-8
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发表时间：
1983
影响因子：
13.8
通讯作者：
J. Sabine
中科院分区：
文献类型：
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作者：
J. Sabine
一个人只有提出正确的问题才能得到正确的答案，这是不言自明的。我们目前对癌症的大部分知识，尤其是对脂质与癌症相互作用的知识，似乎都是由大量的答案（临床、实验和流行病学数据）积累而成，而对真正相关的问题可能是什么，几乎没有或根本没有明确的理解。然而，通过对某种普遍的或统一的概念假设的阐述和考虑，可能会对这一本来令人沮丧的景象产生重要的影响。“癌症的发生、生长和发展取决于脂质状态的改变”就是这样一个假设，本文将进一步发展这一主题。我的目标不仅仅是对现有知识（即我们已经拥有的答案）进行分类，而是激发进一步的批判性质疑，并鼓励基于这些公认重要的问题进行适当的研究。
It is axiomatic that one cannot obtain the right answer until one has asked the right question. Most of our current knowledge of cancer in general, and no less of the lipid-cancer interaction in particular, seems to consist of a vast accumulation of answers (clinical, experimental and epidemiological data) with little or no clear understanding of what the truly relevant questions might be. Significant light, however, could possibly be shed upon this otherwise gloomy scene by the formulation and consideration of some general or unifying conceptual hypothesis.'That the occurrence, growth and development of cancer is dependent upon an altered lipid status', is one such hypothesis and this article will develop this theme further. My aim is not merely to catalogue current knowledge (ie the answers we already have), but rather to stimulate further critical questioning, and to encourage appropriate research based on those questions of agreed importance.