Heart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls.
Heart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls.
复制标题
与健康对照相比，无症状遗传性血色素沉着病受试者进行仰卧运动后心率恢复较低。
DOI：
10.1097/01.hcr.0000270689.63516.92
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发表时间：
2007
影响因子：
3.8
通讯作者：
Rosing,DouglasR
中科院分区：
文献类型：
--
作者：
Arena,Ross;Shizukuda,Yukitaka;Bolan,CharlesD;Tripodi,DorothyJ;Yau,Yu-Ying;Smith,KevinP;Waclawiw,MyronA;Leitman,SusanF;Rosing,DouglasR
方法：无症状HH患者40例(男性27例，女性13例，平均年龄49.7±9.9岁)和健康对照组21例(男性14例，女性7例，平均年龄47.8±8.4岁)。每个受试者都在1周内接受了症状受限的25W仰卧位下肢测功术(SLEE)和Bruce TM运动试验。心率恢复率为运动后1min的值。结果：与SLEE运动试验相比，TM运动试验时两组患者的峰值心率、心率比和最大收缩压均显著降低(P<0.01)，而心率和最大收缩压均显著降低(P<0.05)。01)。HH组睡眠期间HRR显著低于对照组(35.4±9.0比29.2±8.5，P<；讨论：在立位运动中，HH组和对照组的心率恢复无显著差异。然而，HH受试者在SLEE期间的心率显著低于对照组。SLEE期间较高的静脉回流可能允许不同组间动脉顺应性的差异，从而影响HRR。
METHODS:Forty subjects with asymptomatic HH (27 men/13 women; mean age: 49.7±9.9 years) and 21 healthy controls (14 men/7 women; mean age: 47.8±8.4 years) participated in this study. Each subject underwent a symptom-limited 25-W Supine Lower Extremity Ergometry (SLEE) and Bruce TM exercise test within 1 week of each other. Heart rate recovery was the value obtained at 1 minute postexercise. Peak heart rate, systolic blood pressure, and the double product were also obtained during each exercise test.RESULTS:Peak heart rate was significantly higher, whereas HRR and peak systolic blood pressure were significantly lower during TM compared with SLEE exercise testing in both groups (P<. 01). A significantly lower HRR during SLEE in subjects with HH was the only significant difference between groups (35.4±9.0 vs. 29.2±8.5, P<. 01).DISCUSSION:Heart rate recovery was not significantly different between HH and control subjects during upright exercise. However, HRR was significantly lower during SLEE in HH subjects compared with controls. A higher venous return during SLEE may have allowed for differences in arterial compliance between groups to influence HRR.