Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease.
Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease.
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作者：
Della Torre E;Mattoo H;Mahajan VS;Carruthers M;Pillai S;Stone JH
IgG4相关疾病(IgG4-RD)是一种纤维性炎症性疾病，几乎可以影响到每个器官系统。T辅助细胞2型反应被认为是这种疾病的致病因素，据报道，高比例的IgG4-RD患者有长期过敏、外周血嗜酸性粒细胞增多和血清IgE升高。因此，有人提出，过敏机制推动了IgG4-RD。然而，尚未对IgG4-RD患者进行特应性、外周血嗜酸性粒细胞增多、血清IgE浓度的流行病学评估。在这篇手稿中，我们在一大群IgG4-RD患者中评估了这些参数，在这些患者中，各种器官都受到疾病的影响。我们的结果表明，大多数IgG4-RD患者是非特应性的。然而，一组非特应性受试者表现出外周血嗜酸性粒细胞增多和IgE升高，这表明在没有特应性反应的情况下，导致嗜酸性粒细胞增多和IgE升高的原因是IgG4-RD本身固有的过程，而不是特应性自身。
IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that can affect virtually every organ system. T helper type 2 responses have been presumed to be pathogenic in this disease and a high proportion of IgG4-RD patients are reported to have longstanding allergies, peripheral blood eosinophilia, and serum IgE elevation. It has therefore been proposed that allergic mechanisms drive IgG4-RD. However, no epidemiological assessment of atopy, peripheral blood eosinophilia, serumIgEconcentrationshas ever been undertaken in IgG4-RD patients. In the present manuscript, we evaluated these parameters in a large cohort of IgG4-RD patients in whom a wide range of organs were affected by disease. Our results demonstrate that the majority of IgG4-RD patients are non-atopic. Nevertheless, a subset of non-atopic subjects exhibit peripheral blood eosinophilia and elevated IgE, suggesting that processes inherent to IgG4-RD itself rather than atopyper se contribute to the eosinophilia and IgE elevation observed in the absence of atopy.