Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.
Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.
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DOI：
10.1038/s41598-018-24306-1
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发表时间：
2018-04-17
影响因子：
4.6
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Guo F;Gong H;Zhao H;Chen J;Zhang Y;Zhang L;Shi X;Zhang A;Jin H;Zhang J;He Y
Mutations in KRAS exon 2, BRAF and PIK3CA are commonly present in colorectal cancer (CRC) worldwide, but few data about RAS mutations outside KRAS exon 2 are available for Chinese CRCs. We, therefore, determined the mutation frequencies and prognostic values of KRAS exon 2, 3 and 4, NRAS exon 2 and 3, PIK3CA exon 9 and 20, and BRAF exon 15 by PCR and direct sequencing in 353 CRC patients from two Chinese clinical centers. KRAS exon 2, BRAF, PIK3CA mutations were identified in 42.2%, 4.5%, 12.3% of the cases, respectively. We found “rare mutations” in RAS genes in nearly 14% of CRCs-i.e., in almost a quarter (24.0%) of KRAS exon 2 wild type CRCs, including 2.3% in KRAS exon 3, 8.2% in KRAS exon 4 and 3.4% in NRAS. Stage I-III patients with PIK3CA or NRAS mutations developed more distant metastases (3-year risk in PIK3CA mutated and wild type patients: 23.3% vs 11.5%, P = 0.03; multivariate Hazard ratio (HR) = 3.129, P = 0.003; 3-year risk in NRAS mutated and wild type patients: 40.0% vs 12.2%, P = 0.012; multivariate HR = 5.152, P = 0.003). Our data emphasizes the importance of these novel molecular features in CRCs.
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影响因子：
50.5
作者：
Farina-Sarasqueta, A.;van Lijnschoten, G.;van den Brule, A. J. C.
通讯作者：
van den Brule, A. J. C.
KRAS密码子61、146和BRAF突变预测KRAS密码子12和13野生型转移性结直肠癌中对西妥昔单抗和伊立替康的抗性。
影响因子：
8.8
作者：
通讯作者：
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DOI：
10.1158/1078-0432.ccr-12-0605
发表时间：
2012-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gavin PG;Colangelo LH;Fumagalli D;Tanaka N;Remillard MY;Yothers G;Kim C;Taniyama Y;Kim SI;Choi HJ;Blackmon NL;Lipchik C;Petrelli NJ;O'Connell MJ;Wolmark N;Paik S;Pogue-Geile KL
通讯作者：
Pogue-Geile KL
影响因子：
3.8
作者：
Pentheroudakis G;Kotoula V;De Roock W;Kouvatseas G;Papakostas P;Makatsoris T;Papamichael D;Xanthakis I;Sgouros J;Televantou D;Kafiri G;Tsamandas AC;Razis E;Galani E;Bafaloukos D;Efstratiou I;Bompolaki I;Pectasides D;Pavlidis N;Tejpar S;Fountzilas G
通讯作者：
Fountzilas G
DOI：
10.1200/jco.2008.18.6544
发表时间：
2009-03-20
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Ogino S;Nosho K;Kirkner GJ;Shima K;Irahara N;Kure S;Chan AT;Engelman JA;Kraft P;Cantley LC;Giovannucci EL;Fuchs CS
通讯作者：
Fuchs CS