VISCEROTOPIC REPRESENTATION OF THE UPPER ALIMENTARY-TRACT IN THE RAT - SENSORY GANGLIA AND NUCLEI OF THE SOLITARY AND SPINAL TRIGEMINAL TRACTS
VISCEROTOPIC REPRESENTATION OF THE UPPER ALIMENTARY-TRACT IN THE RAT - SENSORY GANGLIA AND NUCLEI OF THE SOLITARY AND SPINAL TRIGEMINAL TRACTS
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DOI：
10.1002/cne.902830207
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发表时间：
1989-05-08
影响因子：
2.5
通讯作者：
MISELIS, RR
中科院分区：
文献类型：
--
作者：
ALTSCHULER, SM;BAO, X;MISELIS, RR
本研究的目的是映射上消化道的感觉神经节的第IX和第X脑神经和在孤束和三叉神经脊束的亚核的viscerotopic表示。因此，在172只大鼠中，将0.5-65 μ l辣根过氧化物酶（HRP）、麦胚凝集素-HRP或霍乱毒素-HRP注射到第IX和第X脑神经的主干和主要分支中以及注射到上消化道和呼吸道的不同水平的肌肉组织和粘膜中。结果表明，第IX和第Xth神经的感觉神经节形成一个融合的神经节块，连续的细胞桥连接神经节复合体的近端和远端部分。将示踪剂注入神经和上消化道的不同部位后，神经节胞体被标记成粗糙的、重叠的拓扑图形。注射到软腭，咽，食管和胃后，顺行标记差异分布在不同的亚核孤束核（NTS）。腭部和咽部注射主要导致NTS的间质亚核和中间亚核以及三叉旁岛（PTI）和三叉神经脊束复合体的标记。食管和胃壁注射导致标记主要是中央亚核和胶状亚核，分别。上消化道迷走-舌咽传入神经在延髓中的分布主要有两组成分，即，内脏定位分布在NTS参与摄食和呼吸反射和分布与抗氟酸性磷酸酶阳性区域的PTI和三叉神经脊束核，推测参与内脏反射介导的伤害性或化学敏感的C纤维。
The aim of this study was to map the viscerotopic representation of the upper alimentary tract in the sensory ganglia of the IXth and Xth cranial nerves and in the subnuclei of the solitary and spinal trigeminal tracts. Therefore, in 172 rats 0.5-65 .mu.l of horseradish peroxidase (HRP), wheat germ agglutinin-HRP, or cholera toxin-HRP were injected into the trunks and major branches of the IXth and Xth cranial nerves as well as into the musculature and mucosa of different levels of the upper alimentary and respiratory tracts. The results demonstrate that the sensory ganglia of the IXth and Xth nerves form a fused ganglionic mass with continuous bridges of cells connecting the proximal and distal portions of the ganglionic complex. Ganglionic perikarya were labeled in crude, overlapping topogrpahical patterns after injections of tracers into nerves and different parts of the upper alimentary tract. After injections into the soft palate, pharynx, esophagus, and stomach, anterograde labeling was differentially distributed in distinct subnuclei in the nucleus of the tractus solitarius (NTS). Palatal and pharyngeal injections resulted primarily in labelling of the interstitial and intermediate subnuclei of the NTS and in the paratrigeminal islands (PTI) and spinal trigeminal complex. Esophageal and stomach wall injections resulted in labeling primarily of the subnucleus centralis and subnucleus gelatinosus, respectively. The distribution of upper alimentary tract vagal-glossopharyngeal afferents in the medulla oblongata has two primary groups of components, i.e., a viscerotopic distribution in the NTS involved in ingestive and respiratory reflexes and a distribution coextensive with fluoride-resistant acid-phosphatase-positive regions of the PTI and spinal trigeminal nucleus presumably involed in visceral reflexes mediated by nociceptive or chemosensitive C fibers.