SLEEP AND WAKING HAVE A MAJOR EFFECT ON THE 24-HR RHYTHM OF CORTICAL TEMPERATURE IN THE RAT
SLEEP AND WAKING HAVE A MAJOR EFFECT ON THE 24-HR RHYTHM OF CORTICAL TEMPERATURE IN THE RAT
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DOI：
10.1177/074873049200700407
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发表时间：
1992-12-01
影响因子：
3.5
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
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作者：
FRANKEN, P;TOBLER, I;BORBELY, AA
通过相关分析和计算机模拟，研究了皮层温度(T(CRT))的时程与睡眠-觉醒交替的关系。这些分析的数据是在为期4天的实验(LD 12：12)中收集的10只大鼠的数据，在此期间，连续8秒测定警戒状态和T(CRT)。第1天记录基线，第2天为睡眠剥夺，第3天和第4天为恢复日。相关分析表明，睡眠和清醒的交替可以解释T(CRT)每小时间隔变化的84%。残差方差表现出24小时的周期性，幅度为0.15摄氏度。在一个为期两天的实验的单独数据集中也得到了类似的结果，该实验由基线日(LD 12：12)和持续黑暗的一天组成。因此，T(CRT)的残差方差的周期性可以被认为是没有被警戒状态所掩盖的昼夜温度节律。在计算机仿真中，T(CRT)的时间过程是基于警戒状态的序列来模拟的，时间分辨率为8秒。假设T(CRT)在清醒和快速眼动(REM)睡眠中按指数饱和函数增加，而在非REM睡眠中按指数下降。模拟可以解释T(CRT)变异的88%-93%。我们得出结论，在大鼠中，T(CRT)变异的大部分是由警戒状态引起的，而一小部分可归因于昼夜起搏器的直接影响。
The relationship between the time course of cortical temperature (T(CRT)) and sleep-wake alternation was investigated by correlation analyses and a computer simulation. The data for these analyses were collected in 10 rats in a 4-day experiment (LD 12:12), during which vigilance states and T(CRT) were determined for consecutive 8-sec epochs. On day 1 baseline recordings were obtained; on day 2 the animals were sleep-deprived; and days 3 and 4 served as recovery days.The correlation analyses revealed that the alternation of sleep and waking accounted for 84% of the variance of T(CRT) when analyzed for hourly intervals. The residual variance displayed a 24-hr periodicity with an amplitude of 0.15-degrees-C. Similar results were obtained in a separate data set of a 2-day experiment, which consisted of a baseline day (LD 12:12) and a day with constant darkness. The periodicity of the residual variance of T(CRT) can therefore be considered to represent the circadian temperature rhythm not masked by the vigilance states.In the computer simulation, the time course of T(CRT) was simulated on the basis of the sequence of the vigilance states with an 8-sec time resolution. It was assumed that T(CRT) increases during waking and rapid-eye-movement (REM) sleep according to an exponential saturating function, and decreases exponentially during non-REM sleep. The simulations could account for 88-93% of the variance of T(CRT).We conclude that in the rat, the major part of the variation of T(CRT) is accounted for by vigilance states, whereas a minor part can be attributed to a direct effect of the circadian pacemaker.