Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
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DOI：
10.1038/ng.635
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发表时间：
2010-09-01
期刊：
影响因子：
30.8
通讯作者：
Nakagawa, Hidewaki
中科院分区：
文献类型：
--
作者：
Takata, Ryo;Akamatsu, Shusuke;Nakagawa, Hidewaki
前列腺癌是全世界男性最常见的恶性肿瘤之一（1），其在亚洲国家的发病率正在上升。我们对4，584名日本前列腺癌男性和8，801名对照受试者进行了全基因组关联研究和复制研究。从先前在欧洲人群中进行的全基因组关联研究中报道的31个相关SNP中，我们证实了9个SNP在P < 1.0 x 10（-7）和10个SNP在P < 0.05时在日本人群中的关联。其余12个SNPs无相关性（P > 0.05）。此外，我们在此报告了5个新的前列腺癌易感性基因座，位于5 p15，（经雷达校正的概率P-GC = 3.9 x 10（-18）），GPRC 6A/RFX 6（P-GC = 1.6 × 10（-12））、13q22（P-GC = 2.8 × 10（-9））、C2orf43（P-GC = 7.5 × 10（-8））和FOXP4（P-GC = 7.6 × 10（-8））。这些发现推进了我们对前列腺癌发生的遗传基础的理解，也突出了不同种族人群中前列腺癌易感性的遗传异质性。
Prostate cancer is one of the most common malignancies in males throughout the world(1), and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P-GC = 3.9 x 10(-18)), GPRC6A/RFX6 (P-GC = 1.6 x 10(-12)), 13q22 (P-GC = 2.8 x 10(-9)), C2orf43 (P-GC = 7.5 x 10(-8)) and FOXP4 (P-GC = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.