Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of HrHp mice
Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of HrHp mice
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DOI：
10.5483/bmbrep.2011.44.7.478
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发表时间：
2011-07-31
期刊：
影响因子：
3.8
通讯作者：
Yoon, Sungjoo Kim
中科院分区：
文献类型：
--
作者：
Choi, Jee-Hyun;Kim, Byong-Kyu;Yoon, Sungjoo Kim
无毛（HR）是一种转录辅因子，在皮肤和大脑中高度表达。为了表征HR在皮肤中表达的影响，我们研究了其在小鼠皮肤和角质形成细胞中对其靶基因的转录调节能力。我们发现，Foxe 1 mRNA的表达被抑制在HR过度表达的皮肤，以及在HR表达角质形成细胞。反过来，Msx 1的表达也随着皮肤和角质形成细胞中Foxe 1的下调而下调。我们还发现Sfrp 1的表达也与Foxe 1的表达相关。进一步研究这些基因的转录调控机制将有助于我们理解毛囊形态发生和周期调控基因之间的关系。[BMB报告2011; 44（7）：478-483]
Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling. [BMB reports 2011; 44(7): 478-483]