* Statement on self‐monitoring of peak expiratory flow in the investigation of occupational asthma
* Statement on self‐monitoring of peak expiratory flow in the investigation of occupational asthma
复制标题
* 关于职业性哮喘调查中呼气峰流量自我监测的声明
DOI：
10.1111/j.1398-9995.1995.tb01211.x
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发表时间：
1995
期刊：
影响因子：
12.4
通讯作者：
R. Coifman
中科院分区：
文献类型：
--
作者：
G. Moscato;J. Godnić;P. Maestrelli;J. Malo;P. Burge;R. Coifman
职业性哮喘是一种以可变流量限制和/或气道高反应性为特征的疾病，其病因和条件可归因于特定的职业环境，而不是工作场所外遇到的刺激(1)。职业性哮喘的调查需要循序渐进，但关键是要确认职业暴露与哮喘之间的因果关系（2,3）。在实验室或工作场所进行的特定吸入激发试验(4)被用来确认工作场所与症状之间的这种关系，将症状与特定物质联系起来，并重现接触与症状发作之间的时间关系。在职业性哮喘的诊断中，也提倡使用连续呼气峰流量（PEE）监测，作为工作场所与症状之间关系的客观确认。自1969年以来，PEF监测一直用于哮喘的调查(6)。然而，Burge等人在1979年首次提出了这种评估职业性哮喘的方法（7,8）。由于其简单性，近年来该方法的受欢迎程度大大增加，但很快就清楚地表明，尽管它简单，但必须仔细定义方法和概念上的几个方面。为了阐明PEF监测在职业性哮喘调查中的不同方面，几位研究人员已经做了大量工作（9-16），尽管有几点仍有待澄清，但已有足够的数据可以对结果进行初步总结。本文件旨在供处理职业性哮喘的医生使用。讨论的要点如下：1.0，PEF和仪器的定义
Occupational asthma is a disease characterized by variable flow limitation and or airway hyperresponsiveness due to causes and conditions attributable to a particular occupational environment and not to stimuli encountered outside the workplace (1). The investigation of occupational asthma requires a stepwise approach, but the crucial point is to confirm the cause-effect relationship between occupational exposure and asthma (2, 3). Specific inhalation challenge tests (4) either in the laboratory or in the workplace are used to confirm this relationship between the workplace and the symptoms, to relate the symptoms to a specific agent, and to reproduce the temporal relationship between exposure and the onset of symptoms. The use of serial peak expiratory flow (PEE) monitoring has also been advocated in the diagnosis of occupational asthma as an objective confirmation of the relationship between the workplace and symptoms. PEF monitoring has been used in the investigation of asthma since 1969 (6). However, Burge et al. were the first, in 1979, to propose this method for the assessment of occupational asthma (7, 8). Because of its simplicity, the popularity of the method has increased greatly in recent years, but it soon became clear that, despite its simplicity, several aspects, both methodological and conceptual, had to be carefully defined. Much work has been done by several researchers to clarify the different aspects of PEF monitoring in the investigation of occupational asthma (9-16) and, although several points have still to be clarified, there are enough data to allow a first summing-up of the results. This document is intended for use by physicians dealing with occupational asthma. The main points addressed are as follows: 1.0, Definition of PEF and instruments