Evolutionary and biomedical insights from the rhesus macaque genome
Evolutionary and biomedical insights from the rhesus macaque genome
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DOI：
10.1126/science.1139247
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发表时间：
2007-04-13
期刊：
影响因子：
56.9
通讯作者：
Zwieg, Ann S.
中科院分区：
文献类型：
--
作者：
Gibbs, Richard A.;Rogers, Jeffrey;Zwieg, Ann S.
恒河猕猴（Macaca Mulatta）是一种丰富的灵长类动物，大约在2500万年前与智人的祖先不同。由于它们在遗传和生理上与人类相似，因此恒河猴是基础和应用生物医学研究中使用最广泛的非人类灵长类动物。我们确定了印度 - 氨基酸杏仁糖女性的基因组序列，并将数据与黑猩猩和人类进行了比较，以揭示祖先灵长类动物基因组的结构，并确定基因家族的阳性选择和谱系特异性扩张和收缩的证据。使用单个动物的序列进行比较来研究其潜在的遗传多样性。猕猴基因组蓝图的完整描述增强了这种动物模型在生物医学研究中的效用，并提高了我们对该物种基本生物学的理解。
The rhesus macaque ( Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.