Enhanced IMC for Glucose Control in Type I Diabetics Using a Detailed Physiological Model
Enhanced IMC for Glucose Control in Type I Diabetics Using a Detailed Physiological Model
复制标题
使用详细的生理模型增强 IMC 控制 I 型糖尿病患者的血糖
DOI：
10.1205/fbp.05070
复制
发表时间：
2006
影响因子：
4.6
通讯作者：
S. Lakshminarayanan
中科院分区：
文献类型：
--
作者：
Y. Ramprasad;G. P. Rangaiah;S. Lakshminarayanan
对1型糖尿病患者来说，使用“最佳”量的胰岛素来维持血糖浓度在正常范围内是至关重要的。本研究针对糖尿病患者开发了内模控制（IMC）和增强型内模控制（EIMC），因为它们结构简单，具有较好的干扰衰减和不确定性降低效果。通过一阶加时滞（FOPTD）模型，对名义糖尿病患者详细的第一原理生理模型的阶跃响应进行近似，然后将该模型用于开发IMC和EIMC。这两种控制器的评估基于其跟踪正常血糖设定点81.1 mg dl−1的能力，同时在名义患者病例和大约580例受干扰的患者病例中拒绝进食干扰(s)，考虑患者模型中±40%的参数变化，并使用第一原理模型进行模拟。结果表明，EIMC优于IMC，在90%以上的患者模型中，前者可以将血糖维持在低血糖危险范围以上。
Administering ‘optimal’ amount of insulin to maintain the blood glucose concentration in the normoglycemic range is vital in Type 1 diabetics. In this study, internal model control (IMC) and enhanced IMC (EIMC) are developed for a diabetic due to their simple structure, better disturbance attenuation and uncertainty reduction. The step response of a detailed, first principles physiological model of the nominal diabetic patient is approximated by the first order plus time delay (FOPTD) model, which is then used for developing the IMC and EIMC. The two controllers are assessed based on their ability to track normoglycemic set point of 81.1 mg dl −1 while rejecting meal disturbance(s) both in the nominal patient case and about 580 perturbed patient cases, obtained by considering ±40% parametric variations in the patient model and all simulated using the first principles model. The results show that the EIMC is better than the IMC, and that the former can maintain the blood glucose above the dangerous hypoglycemic range in more than 90% of patient models studied.
影响因子：
15.9
作者：
BERGMAN, RN;PHILLIPS, LS;COBELLI, C
通讯作者：
COBELLI, C