INFECTION OF HUMANS AND HORSES BY A NEWLY DESCRIBED MORBILLIVIRUS
INFECTION OF HUMANS AND HORSES BY A NEWLY DESCRIBED MORBILLIVIRUS
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DOI：
10.5694/j.1326-5377.1995.tb126050.x
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发表时间：
1995-06-19
影响因子：
11.4
通讯作者：
SHERIDAN, JW
中科院分区：
文献类型：
--
作者：
SELVEY, LA;WELLS, RM;SHERIDAN, JW
目的：描述一起影响人马的病毒感染暴发的临床和流行病学特征。背景：布里斯班郊区亨德拉的马厩。研究对象：受影响的马匹和人类，以及有风险的人类接触者。结果：一匹怀孕的母马在抵达布里斯班其他地方的围场两天后死亡。8至11天后，同一马厩或相邻马厩的另外17匹马报告了疾病（抑郁、厌食症、发烧、呼吸困难、共济失调、心动过速、呼吸急促和流鼻水）。14匹马死亡或被杀死。在这匹母马死后的第五天和第六天，一名马厩管理员和一名驯马师都患上了类似流感的疾病，他们都曾密切接触过这匹病母马的粘液分泌物。这位教练康复后出现肺炎、呼吸衰竭、肾衰竭和动脉血栓，并在入院7天后死于心脏骤停。从他的肾脏中培养出的麻疹病毒与从五匹受感染马的肺部分离出的病毒完全相同。两名受影响的人和另外八匹马的血清感染呈阳性，在受感染马的脾脏/肺匀浆攻击后，在健康马中复制了这种感染。157名与马厩或病马或人有过接触的人没有血清学感染的证据。结论：先前未描述的麻疹病毒可能感染了21匹马和2人；1人和14匹马死亡。在人类中没有发现进一步的病例，这表明该病毒的传染性较低。感染源仍未确定。
Objective: to describe the clinical and epidemiological features of an outbreak of a viral infection affecting humans and horses.Setting: Stables in Hendra, a suburb of Brisbane.Subjects: affected horses and humans, and at-risk human contacts.Results: A pregnant mare died two days after arrival from a paddock elsewhere in Brisbane. Eight to 11 days later, illness (depression, anorexia, fever, dyspnoea, ataxia, tachycardia, tachypnoea and nasal discharge) was reported among 17 other horses from the same or an adjoining stable. Fourteen horses died or were put down. five and six days after the index mare's death, a stable-hand and then a horse trainer, both of whom had had close contact with the sick mare's mucous secretions, developed influenza-like illnesses. The stable-hand recovered out the the trainer developed pneumonitis, respiratory failure, renal failure and arterial thrombosis, and died from a cardiac arrest seven days after admission to hospital. A morbillivirus cultured from his kidney was identical to one isolated from the lungs of five affected horses. The two affected humans and eight other horses were seropositive for the infection, which was reproduced in healthy horses following challenge by spleen/lung homogenates from infected horses. There was no serological evidence of infection in 157 humans who had had contact with the stables or the sick horses or humans.Conclusions: A previously undescribed morbillivirus infected a probable 21 horses and two humans; one human and 14 horses died. That no further cases were detected among humans suggests that the virus was of low infectivity. The source of infection remains undetermined.