2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in benign prostate and subsequent risk for prostate cancer.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in benign prostate and subsequent risk for prostate cancer.
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2-Amino-1-甲基-6-苯基咪唑唑[4,5-B]吡啶（PHIP） - 良性前列腺中的DNA加合物，后来患前列腺癌的风险。
DOI：
10.1002/ijc.28092
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发表时间：
2013-08-15
影响因子：
6.4
通讯作者：
Rybicki, Benjamin A.
中科院分区：
文献类型：
--
作者：
Tang, Deliang;Kryvenko, Oleksandr N.;Wang, Yun;Trudeau, Sheri;Rundle, Andrew;Takahashi, Satoru;Shirai, Tomoyuki;Rybicki, Benjamin A.
尽管有令人信服的证据表明，2-氨基-1-甲基-6-苯基咪唑[4，5-B]吡啶（PhIP）-一种在高温下烹饪肉类产生的杂环胺-在动物模型中具有致癌性，但仍不清楚PhIP暴露是否会导致人类癌症风险增加。PhIP-DNA加合物的水平进行了测量，从534例前列腺癌病例对照对嵌套在一个历史队列的男性与组织病理学良性前列腺标本。我们估计了与高加合物水平相关的前列腺癌的总体和种族分层风险。良性前列腺中PhIP-DNA加合物水平在白人中显著高于非裔美国人（0.274光密度单位（OD）±0.059对0.256 OD ±0.054; p<0.0001）。PhIP-DNA加合物水平最高四分位数的男性前列腺癌风险适度增加（比值比（OR）= 1.25; 95%置信区间（CI）= 0.76-2.07）。在亚组分析中，在队列入组后4年以上（OR=2.74; 95% CI=1.01-7.42）或65岁以下（OR=2.80; 95% CI=0.87-8.97）诊断的白色患者中观察到最高风险估计值。在白人中，与高级别前列腺上皮内瘤变结合PhIP-DNA加合物水平升高相关的癌症风险（OR=3.89; 95%CI =1.56-9.73）大于与单独任一因素相关的风险。总体而言，PhIP-DNA加合物水平升高不会显著增加前列腺癌风险。然而，我们的数据显示，白色男性在良性前列腺组织中的PhIP-DNA加合物水平高于非洲裔美国男性，并表明在某些白色男性亚组中，高PhIP-DNA加合物水平可能使前列腺癌风险增加。
Despite convincing evidence that 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)—a heterocyclic amine generated by cooking meats at high temperatures—is carcinogenic in animal models, it remains unclear whether PhIP exposure leads to increased cancer risk in humans. PhIP-DNA adduct levels were measured in specimens from 534 prostate cancer case-control pairs nested within a historical cohort of men with histopathologically benign prostate specimens. We estimated the overall and race-stratified risk of subsequent prostate cancer associated with higher adduct levels. PhIP-DNA adduct levels in benign prostate were significantly higher in Whites than African Americans (0.274 Optical Density Units (OD) ±0.059 vs. 0.256 OD ±0.054; p<0.0001). Prostate cancer risk for men in the highest quartile of PhIP-DNA adduct levels was modestly increased (Odds Ratio (OR) = 1.25; 95% confidence interval (CI) = 0.76-2.07). In subset analyses, the highest risk estimates were observed in White patients diagnosed more than 4 years after cohort entry (OR=2.74; 95% CI=1.01-7.42) or under age 65 (OR=2.80; 95% CI=0.87-8.97). In Whites, cancer risk associated with high grade prostatic intraepithelial neoplasia combined with elevated PhIP-DNA adduct levels (OR=3.89; 95% CI=1.56-9.73) was greater than risk associated with either factor alone. Overall, elevated levels of PhIP-DNA adducts do not significantly increase prostate cancer risk. However, our data show that White men have higher PhIP-DNA adduct levels in benign prostate tissue than African American men, and suggest that in certain subgroups of White men high PhIP-DNA adduct levels may predispose to an increased risk for prostate cancer.
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影响因子：
4.1
作者：
Malfatti, MA;Felton, JS
通讯作者：
Felton, JS
影响因子：
4.7
作者：
FELTON, JS;KNIZE, MG;HATCH, FT
通讯作者：
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影响因子：
4.1
作者：
LIN, DX;KADERLIK, KR;KADLUBAR, FF
通讯作者：
KADLUBAR, FF
DOI：
10.1016/j.mrfmmm.2006.05.023
发表时间：
2006-10-10
影响因子：
2.3
作者：
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通讯作者：
Strom, Sara S.
影响因子：
7.5
作者：
Kryvenko, Oleksandr N.;Jankowski, Michelle;Rybicki, Benjamin A.
通讯作者：
Rybicki, Benjamin A.