Nociceptive Pathway in the Cockroach Periplaneta americana
Nociceptive Pathway in the Cockroach Periplaneta americana
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DOI：
10.3389/fphys.2019.01100
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发表时间：
2019-08-21
影响因子：
4
通讯作者：
Libersat, Frederic
中科院分区：
文献类型：
--
作者：
Emanuel, Stay;Libersat, Frederic
检测和避免环境威胁（例如可能造成伤害的威胁）对于动物的生存至关重要。在这项工作中，我们研究了美洲大蠊昆虫的伤害感受途径，从检测有害刺激到伤害行为。我们发现，施加到蟑螂角质层的有害刺激会引起感觉轴突的反应，这与感觉传入神经中的触觉感觉轴突不同。我们还揭示了神经索中突触后投射中间神经元对触觉刺激和伤害性刺激的诱发反应的差异。蟑螂神经索中的有害刺激由直径不同于触觉和风敏纤维的纤维编码，传导速度较慢，为 2-3 m/s。此外，颈部结缔组织的记录显示伤害性信息到达头部神经节。去除头部神经节会导致伤害反应急剧下降，表明头部神经节和神经索都参与处理伤害性刺激。
Detecting and avoiding environmental threats such as those with a potential for injury is of crucial importance for an animal's survival. In this work, we examine the nociceptive pathway in an insect, the cockroach Periplaneta americana, from detection of noxious stimuli to nocifensive behavior. We show that noxious stimuli applied to the cuticle of cockroaches evoke responses in sensory axons that are distinct from tactile sensory axons in the sensory afferent nerve. We also reveal differences in the evoked response of post-synaptic projection interneurons in the nerve cord to tactile versus noxious stimuli. Noxious stimuli are encoded in the cockroach nerve cord by fibers of diameter different from that of tactile and wind sensitive fibers with a slower conduction velocity of 2-3 m/s. Furthermore, recording from the neck-connectives show that the nociceptive information reaches the head ganglia. Removing the head ganglia results in a drastic decrease in the nocifensive response indicating that the head ganglia and the nerve cord are both involved in processing noxious stimuli.