The role of the liver in sepsis.
The role of the liver in sepsis.
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DOI：
10.3109/08830185.2014.889129
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发表时间：
2014-11
影响因子：
5
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Yan J;Li S;Li S
尽管在脓毒症的临床管理方面取得了进展，但脓毒症的发病率和死亡率仍然很高。对于重要器官，尤其是肝脏，炎症发病机制和导致败血症死亡的器官损伤尚未完全了解。直到最近，肝脏在脓毒症中的作用才开始被揭示。预先存在的肝功能障碍是感染进展为脓毒症的风险因素。脓毒症后肝功能损害是多器官功能障碍和脓毒症死亡的独立危险因素。肝脏作为淋巴器官对脓毒症作出反应。肝脏介导的免疫应答在脓毒症中是一把双刃剑，它负责清除细菌和毒素，但也会引起炎症、免疫抑制和器官损伤。减轻肝损伤和恢复肝功能可降低脓毒症患者的发病率和死亡率。本文综述了肝脏在脓毒症宿主免疫反应和临床结局中的核心作用。
Despite the progress made in the clinical management of sepsis, sepsis morbidity and mortality rates remain high. The inflammatory pathogenesis and organ injury leading to death from sepsis are not fully understood for vital organs, especially the liver. Only recently has the role of the liver in sepsis begun to be revealed. Pre-existing liver dysfunction is a risk factor for the progression of infection to sepsis. Liver dysfunction after sepsis is an independent risk factor for multiple organ dysfunction and sepsis-induced death. The liver works as a lymphoid organ in response to sepsis. Acting as a double-edged sword in sepsis, the liver-mediated immune response is responsible for clearing bacteria and toxins but also causes inflammation, immunosuppression, and organ damage. Attenuating liver injury and restoring liver function lowers morbidity and mortality rates in patients with sepsis. This review summarizes the central role of liver in the host immune response to sepsis and in clinical outcomes.
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影响因子：
6.3
作者：
Iwashyna TJ;Cooke CR;Wunsch H;Kahn JM
通讯作者：
Kahn JM
DOI：
10.4049/jimmunol.0801463
发表时间：
2009-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hu CK;Venet F;Heffernan DS;Wang YL;Horner B;Huang X;Chung CS;Gregory SH;Ayala A
通讯作者：
Ayala A
影响因子：
3.1
作者：
Gonnert, Falk A.;Kunisch, Elke;Kinne, Raimund W.
通讯作者：
Kinne, Raimund W.
影响因子：
8.8
作者：
Crouser, Elliott D.;Julian, Mark W.;Cook, Charles H.
通讯作者：
Cook, Charles H.
影响因子：
8.8
作者：
Angus, D C;Linde-Zwirble, W T;Pinsky, M R
通讯作者：
Pinsky, M R