Low circulating protein C levels are associated with lower leg ulcers in patients with diabetes.
Low circulating protein C levels are associated with lower leg ulcers in patients with diabetes.
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DOI：
10.1155/2013/719570
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发表时间：
2013
影响因子：
--
通讯作者：
Jackson CJ
中科院分区：
文献类型：
--
作者：
Whitmont K;Fulcher G;Reid I;Xue M;McKelvey K;Xie Y;Aboud M;Ward C;Smith MM;Cooper A;March L;Jackson CJ
活化蛋白C（APC）促进血管生成和上皮再生，加速糖尿病溃疡的愈合。本研究的目的是确定糖尿病患者下肢溃疡的发生率与APC前体蛋白C（PC）血浆水平之间的关系。将下肢溃疡>6个月的糖尿病患者（n = 36）与年龄、糖尿病类型和性别匹配的糖尿病但无溃疡的受试者（n = 36，对照组）进行比较。使用常规PC比色法评估总PC。经年龄校正、性别和糖尿病类型匹配后，溃疡患者血浆PC水平（103.3 ± 22.7，平均值± SD）显著低于对照组（127.1 ± 34.0）（P < 0.001）。溃疡类型（神经性、缺血性或混合性）不是血浆PC水平的显著协变量（P = 0.35）。两组中PC水平与性别、糖尿病类型、HbA 1c或C-反应蛋白均无相关性。总之，循环PC水平降低与糖尿病患者下肢溃疡相关，并可能易患下肢溃疡。
Activated protein C (APC) promotes angiogenesis and reepithelialisation and accelerates healing of diabetic ulcers. The aim of this study was to determine the relationship between the incidence of lower leg ulcers and plasma levels of APC's precursor, protein C (PC), in diabetic patients. Patients with diabetes who had a lower leg ulcer(s) for >6 months (n = 36) were compared with age-, type of diabetes-, and sex-matched subjects with diabetes but without an ulcer (n = 36, controls). Total PC was assessed using a routine PC colorimetric assay. There was a significantly (P < 0.001) lower level of plasma PC in patients with ulcers (103.3 ± 22.7, mean ± SD) compared with control (127.1 ± 34.0) subjects, when corrected for age and matched for gender and type of diabetes. Ulcer type (neuropathic, ischaemic, or mixed) was not a significant covariate for plasma PC levels (P = 0.35). There was no correlation between PC levels and gender, type of diabetes, HbA1c, or C-reactive protein in either group. In summary, decreased circulating PC levels are associated with, and may predispose to, lower leg ulceration in patients with diabetes.
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影响因子：
2.9
作者：
Jackson, CJ;Xue, ML;March, L
通讯作者：
March, L
影响因子：
3.7
作者：
Xue, ML;Thompson, P;Jackson, C
通讯作者：
Jackson, C
影响因子：
15.9
作者：
Kurosawa, S;StearnsKurosawa, DJ;Esmon, CT
通讯作者：
Esmon, CT
影响因子：
7.7
作者：
VUKOVICH, TC;SCHERNTHANER, G
通讯作者：
SCHERNTHANER, G
影响因子：
--
作者：
Whitmont, Kaley;Reid, Ian;Jackson, Chris
通讯作者：
Jackson, Chris