Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity
Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity
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DOI：
10.1161/01.hyp.0000160318.46725.46
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发表时间：
2005-04-01
期刊：
影响因子：
8.3
通讯作者：
Somers, VK
中科院分区：
文献类型：
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作者：
Narkiewicz, K;Phillips, BG;Somers, VK
女性心血管疾病与年龄相关的发病率比男性显著增加的机制尚不清楚。我们测试了这样一个假设，即年龄对女性的交感流量的影响比男性更大。对120例20~72岁健康男性和96例健康女性的肌交感神经活动(MSNA)、血压和心率进行了测量。男性和女性的MSNA均随年龄增长而增加，但年龄可解释女性MSNA变异的53%和男性MSNA变异的8%。回归直线的斜率和截距在男女之间均有显著差异(P
The mechanisms mediating the more striking age related increase in cardiovascular disease in women than in men are poorly understood. We tested the hypothesis that aging has a greater impact on sympathetic traffic in women than in men. Muscle sympathetic nerve activity (MSNA), blood pressure, and heart rate were measured in 120 healthy males and 96 healthy females aged 20 to 72 years. MSNA increased with age in both sexes, but age explained 53% of MSNA variance in female subjects and only 8% of MSNA variance in male subjects. Both the slope and intercept of the regression lines were significantly different between male and female groups (P