ANTIGENIC SHIFT OF VISNA VIRUS IN PERSISTENTLY INFECTED SHEEP
ANTIGENIC SHIFT OF VISNA VIRUS IN PERSISTENTLY INFECTED SHEEP
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DOI：
10.1126/science.195339
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
CHASE, J
中科院分区：
文献类型：
--
作者：
NARAYAN, O;GRIFFIN, DE;CHASE, J
从持续感染绵羊中分离的维斯纳病毒与用于接种的噬斑纯化病毒在抗原性上不同。抗体压力下的抗原变异体的选择，认为发生在体内，在绵羊细胞培养物接种噬斑纯化维斯纳病毒，并保持在抗体中再现。抗原转移可能是慢性或复发性病毒感染中病毒持续存在的机制。
Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenic variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.