Relationship between normal tension glaucoma and Flammer syndrome.
Relationship between normal tension glaucoma and Flammer syndrome.
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DOI：
10.1007/s13167-017-0097-3
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Kim DM
中科院分区：
文献类型：
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作者：
Konieczka K;Choi HJ;Koch S;Fankhauser F;Schoetzau A;Kim DM
除眼压外，血管因素在青光眼视神经病变的发病机制中也起着重要作用。其中一个潜在的血管因素是弗拉默综合征。本研究的目的是确定韩国人群中正常紧张性青光眼患者是否比对照组更常出现Flammer综合征的体征和症状。246名正常紧张性青光眼患者和1116名对照者填写了一份关于15种Flammer综合征体征和症状的多项选择问卷。Flammer综合征的15个体征和症状中的7个（药物敏感性增加、嗅觉良好、可逆性皮肤斑点、耳鸣、睡眠时间长、完美主义倾向和手/脚冷）在正常紧张性青光眼患者中明显比在对照组中呈阳性。另外六种体征和症状（偏头痛、低血压、头痛、头晕、痛感增加和感觉寒冷）也更常发生，但没有达到统计学意义。在对照组中，只有两项（低体重和减少口渴感）更频繁（不显著）呈阳性。正常张力性青光眼与Flammer综合征之间存在关联。如果未来的研究证实这种关系，治疗Flammer综合征可能有助于预防正常的紧张性青光眼或减缓其进展。
Besides intraocular pressure, vascular factors play a role in the pathogenesis of glaucomatous optic neuropathy. One of these potential vascular factors is Flammer syndrome. The purpose of the present study was to determine in a Korean population whether signs and symptoms of Flammer syndrome occur more often in normal tension glaucoma patients than in control subjects. Two hundred forty-six normal tension glaucoma patients and 1116 control subjects responded to a multiple-choice questionnaire asking about 15 signs and symptoms of Flammer syndrome. Seven of the 15 signs and symptoms of Flammer syndrome (increased drug sensitivity, good smell perception, reversible skin blotches, tinnitus, long sleep onset time, tendency to perfectionism, and cold hands/feet) were significantly more often positive in normal tension glaucoma patients than in controls. Six additional signs and symptoms (migraines, low blood pressure, headaches, dizziness, increased pain sensation, and feeling cold) also occurred more often, but did not reach statistical significance. Only two items (low body weight and reduced feeling of thirst) were more frequently (not significant) positive in the controls. There is an association between normal tension glaucoma and Flammer syndrome. If future studies confirm this relationship, treatment of Flammer syndrome may help to prevent normal tension glaucoma or to slow down its progression.