Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis
Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis
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DOI：
10.1128/iai.66.1.356-360.1998
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发表时间：
1998-01-01
影响因子：
3.1
通讯作者：
Gilmore, MS
中科院分区：
文献类型：
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作者：
Booth, MC;Hatter, KL;Gilmore, MS
对从多个临床中心收集的39株金黄色葡萄球菌和28株粪肠球菌眼内炎分离株进行基因组DNA指纹分析。在21个S.金黄色葡萄球菌基因组DNA指纹图谱鉴定，5个克隆型回收多个无关的患者，占58.9%（23 39）的分析菌株。与具有独特基因组DNA指纹图谱的菌株相比，S.金黄色葡萄球菌克隆型出现一次以上更可能导致视力为20/200或更差（P = 0.036 [卡方检验]）。与S. aureus分离株、E.粪菌眼内炎分离株是克隆多样性群体，富集了已知毒素溶细胞素的表达，溶细胞素是质粒编码的。
Genomic DNA fingerprint analysis was performed on 39 Staphylococcus aureus and 28 Enterococcus faecalis endophthalmitis isolates collected from multiple clinical centers. Among 21 S. aureus genomic DNA fingerprint patterns identified, five clonotypes were recovered from multiple unrelated patients and accounted for 58.9% (23 of 39) of the isolates analyzed. Compared with strains having unique genomic DNA fingerprint patterns, the S. aureus clonotypes occurring more than once were more likely to result in visual acuities of 20/200 or worse (P = 0.036 [chi(2) test]). In contrast to the S. aureus isolates, the E. faecalis endophthalmitis Isolates were a clonally diverse population, enriched for the expression of a known toxin, cytolysin, which is plasmid encoded.