Residential dampness problems and symptoms and signs of bronchial obstruction in young Norwegian children
Residential dampness problems and symptoms and signs of bronchial obstruction in young Norwegian children
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DOI：
10.1164/ajrccm.157.2.9706033
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发表时间：
1998-02-01
影响因子：
24.7
通讯作者：
Jaakkola, JJK
中科院分区：
文献类型：
--
作者：
Nafstad, P;Oie, L;Jaakkola, JJK
为了评估潮湿问题和屋尘螨暴露在生命早期支气管阻塞发展中的作用，对 1992 年至 1993 年出生于奥斯陆的 3,754 名儿童进行了为期两年的跟踪调查。支气管阻塞定义为两次或两次以上出现阻塞症状和体征，或者一次持续 1 个月或更长时间。对 251 例支气管阻塞病例（有效率：98%）及其 251 例配对对照进行了匹配病例对照研究。通过家访和问卷调查收集有关家庭潮湿问题、屋尘螨暴露和潜在混杂因素的信息。 27%的病例和14%的对照者的家中发现潮湿问题，而11名病例（4.5%）和3名对照者（1.2%）的床上发现屋尘螨过敏原浓度>2μg/g灰尘。在控制 fbr 潜在混杂因素的条件逻辑回归分析中，确认的潮湿问题增加了支气管阻塞的风险（调整后的比值比：3.8；95% 置信区间：2.0-7.2）。接触屋尘螨过敏原 > 2 mu g/g 粉尘会增加支气管阻塞的风险（调整后的比值比：2.8；95% 置信区间：0.7-11.7）。奥斯陆住宅的潮湿问题似乎会增加幼儿支气管阻塞的症状和体征，但显然不会增加他们接触屋尘螨的机会。
To assess the role of dampness problems and house dust mite exposure in the development of bronchial obstruction in early life, a cohort of 3,754 children born in Oslo during 1992 and 1993 was followed for 2 yr. Bronchial obstruction was defined as two or more episodes with symptoms and signs of obstruction or one lasting 1 mo or more. A matched case-control study was carried out in 251 cases of bronchial obstruction (response rate: 98%) and their 251 paired controls. Information on home dampness problem(s), house dust mite exposure, and potential confounders was collected during home visits and by questionnaires. Dampness problems were confirmed in the homes of 27% of the cases and 14% of the controls, while a concentration of Dermatophagoides pteronyssinus allergens > 2 mu g/g dust was found in the beds of 11 (4.5%) cases and three (1.2%) controls. In conditional logistic regression analysis controlling fbr potential confounders, confirmed dampness problems increased the risk of bronchial obstruction (adjusted odds ratio: 3.8; 95% confidence interval: 2.0-7.2). Exposure to D. pteronyssinus allergens > 2 mu g/g dust increased the risk of bronchial obstruction (adjusted odds ratio: 2.8; 95% confidence interval: 0.7-11.7). Residential dampness problems in Oslo dwellings seem to increase symptoms and signs of bronchial obstruction in young children, apparently without increasing their exposure to house dust mites.