Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase
Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase
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DOI：
10.1002/jcb.20662
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发表时间：
2005-12-15
影响因子：
4
通讯作者：
Brock, TG
中科院分区：
文献类型：
--
作者：
Brock, TG
白三烯是参与自分泌和旁分泌细胞信号传递的脂质信使。它们是由花生四烯酸通过5-脂氧合酶途径合成的。目前这种酶途径的模型认识到，启动白三烯合成的关键步骤是钙介导的酶，包括5-脂氧合酶，到细胞内膜的运动。然而，5-脂氧合酶可以在钙激活之前输入或输出到细胞核。因此，它的亚细胞定位将影响它被钙激活的能力，以及它与膜的结合和它与其他酶的相互作用。这篇评论集中于5-脂氧合酶在决定其调节和最终白三烯合成中的作用。J.细胞。生物化学。96：1203-1211,2005。(C)2005年Wiley-Liss，Inc.
Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5-lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium-mediated movement of enzymes, including 5-lipoxygenase, to intracellular membranes. However, 5-lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5-lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. 96: 1203-1211, 2005. (c) 2005 Wiley-Liss, Inc.