Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient.
Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient.
复制标题
大鼠基底外侧杏仁核兴奋性毒性损伤后条件性恐惧的逆行消除：缺乏时间梯度。
DOI：
10.1037//0735-7044.110.4.718
复制
发表时间：
1996
影响因子：
1.9
通讯作者：
Fanselow,MS
中科院分区：
文献类型：
--
作者：
Maren,S;Aharonov,G;Fanselow,MS
在 80 只大鼠中检查了基底外侧杏仁核 (BLA) 在巴甫洛夫恐惧条件反射的获得和表达中的作用。在巴甫洛夫恐惧条件反射之前 7 天或之后 1、14 或 28 天，使用 N-甲基-{d}-天冬氨酸在 BLA 中造成兴奋性毒性损伤。条件反射包括在一个新颖的房间里将三种音调与令人厌恶的足部电击结合起来，而冻结行为则作为有条件恐惧的指标。 BLA 损伤消除了所有训练到损伤间隔内对情境和声学条件刺激的条件冻结，并且损伤的程度不随训练到损伤间隔而变化。重新获取训练提高了 BLA 损伤大鼠的冻结水平，但与对照组相比并没有降低其缺陷程度。这些结果表明，BLA 中的神经元在条件恐惧的表达中具有持久的作用。（PsycINFO 数据库记录 (c) 2019 APA，保留所有权利）
The role of the basolateral amygdala (BLA) in the acquisition and expression of Pavlovian fear conditioning was examined in 80 rats. Excitotoxic lesions were made in the BLA using N-methyl-{d}-aspartate 7 days before or 1, 14, or 28 days after Pavlovian fear conditioning. Conditioning consisted of three pairings of a tone with an aversive footshock in a novel chamber, and freezing behavior served as an index of conditional fear. BLA lesions abolished conditional freezing to both the contextual and acoustic conditional stimuli at all training-to-lesion intervals, and the magnitude of the impairment did not vary as a function of the training-to-lesion interval. Reacquisition training elevated levels of freezing in rats with BLA lesions but did not reduce the magnitude of their deficit in relation to that of controls. These results reveal that neurons in the BLA have an enduring role in the expression of conditional fear.(PsycINFO Database Record (c) 2019 APA, all rights reserved)