Endotoxin: The uninvited guest
Endotoxin: The uninvited guest
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DOI：
10.1016/j.biomaterials.2005.04.063
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发表时间：
2005-12-01
期刊：
影响因子：
14
通讯作者：
Sefton, MV
中科院分区：
文献类型：
--
作者：
Gorbet, MB;Sefton, MV
在生物材料合成和生物相容性评价的实验室环境中，我们发现内毒素污染难以避免，不容忽视。在那些已知存在内毒素的相对较少的情况下，已经清楚地表明，内毒素会显著影响所观察到的生物反应，因此混淆了材料的任何作用。这篇简短的综述解释了内毒素是什么，如何检测和去除它，以及它对生物材料的生物反应的影响。我们提倡对生物材料和用于生物材料实验评估的试剂进行常规内毒素检测，这应该是每个科学家的责任，以确保任何生物材料研究的有效性。(c) 2005 Elsevier Ltd版权所有。
In the laboratory environment where biomaterials are synthesized and their biocompatibility assessed, we find that endotoxin contamination is hard to avoid and must not be ignored. In those relatively few cases where endotoxin was known to be present, it has been clearly shown that endotoxin call significantly affect the biological response observed and hence confound any effect of the material. This short review explains what endotoxin is, how to test for it and remove it and what its effect on the biological response to biomaterials is. We advocate routine testing of endotoxin on biomaterials and of reagents used in experimental evaluation of biomaterials and this should be the responsibility of every scientist to ensure the validity of any biomaterial study. (c) 2005 Elsevier Ltd. All rights reserved.