The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study.
The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study.
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健康献血者对 3 剂灭活 COVID-19 疫苗接种的抗体反应的持续时间和广度：一项观察性研究
DOI：
10.3389/fimmu.2022.1027924
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发表时间：
2022
影响因子：
7.3
通讯作者：
Yuan, Quan
中科院分区：
文献类型：
--
作者：
Ou, Shanhai;Huang, Zehong;Lan, Miaoling;Ye, Jianghui;Chen, Jijin;Guo, Huilin;Xiao, Jin;Zhuang, Shucheng;Wu, Jiahuang;Yang, Chuanlai;Fang, Mujin;Su, Yingying;Wu, Ting;Ge, Shengxiang;Cheng, Tong;Zhang, Yongchang;Lin, Yongcai;Zhang, Yali;Chen, Guowei;Yuan, Quan
我们的目的是评估健康献血者接种新冠肺炎灭活疫苗后产生抗体的持续时间和广度。我们对接受两剂(n=357)或三剂新冠肺炎灭活疫苗(n=301)的658名献血者的1,417份样本进行了血清学测试。我们还评估了94名参与者在加强免疫前后抗体反应的变化，以及他们在加强接种后对当前变异体的中和广度。在接种疫苗后，无论是2剂还是3剂，中和抗体(NAB)在大约一个月内达到峰值，血清阳性率约为97%，但随后随着时间的推移而下降。在末次免疫后6~8个月采集的血浆中，接种2剂和3剂的人群NAB抗体阳性率分别为37%和85%。94份来自三次免疫供者(n=94)的血浆样本(接种后2-6周)的NAB对祖先B.1的几何平均滴度为145.3(95%可信区间：117.2-180.1)，对Delta变异体略微降低了1.7倍，但在中和Omicron变异体时显著降低了4-6倍，包括BA.1(5.6倍)、BA.1.1(6.0倍)、BA.2(4.2倍)、B.2.12.1(6.2倍)和BA.4/5(6.5倍)。这些发现表明，第三剂新冠肺炎灭活疫苗延长了健康人群的抗体持续时间，但诱导的NAB对循环中的Omiron变异体的中和效率较低。
We aimed to evaluate the duration and breadth of antibodies elicited by inactivated COVID-19 vaccinations in healthy blood donors. We performed serological tests on 1,417 samples from 658 blood donors who received two (n=357), or three (n=301) doses of COVID-19 inactivated vaccine. We also accessed the change in antibody response before and after booster vaccination in 94 participants and their neutralization breadth to the current variants after the booster. Following vaccination, for either the 2- or 3-dose, the neutralizing antibodies (nAbs) peaked with about 97% seropositivity approximately within one month but subsequently decreased over time. Of plasmas collected 6-8 months after the last immunization, the nAb seropositivities were 37% and 85% in populations with 2-dose and 3-dose vaccinations, respectively. The nAbs of plasma samples (collected between 2-6 weeks after the 3rd dose) from triple-vaccinated donors (n=94) showed a geometric mean titer of 145.3 (95% CI: 117.2 to 180.1) against the ancestral B.1, slightly reduced by 1.7-fold against Delta variant, but markedly decreased by 4-6 fold in neutralizing Omicron variants, including the sub-lineages of BA.1 (5.6-fold), BA.1.1 (6.0-fold), BA.2 (4.2-fold), B.2.12.1 (6.2-fold) and BA.4/5 (6.5-fold). These findings suggested that the 3rd dose of inactivated COVID-19 vaccine prolongs the antibody duration in healthy populations, but the elicited-nAbs are less efficient in neutralizing circulating Omicron variants.
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影响因子：
64.5
作者：
Sette A;Crotty S
通讯作者：
Crotty S
影响因子：
16.6
作者：
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通讯作者：
Monteiro de Andrade, Luiz Odorico
影响因子：
56.3
作者：
McMenamin, Martina E.;Nealon, Joshua;Lin, Yun;Wong, Jessica Y.;Cheung, Justin K.;Lau, Eric H. Y.;Wu, Peng;Leung, Gabriel M.;Cowling, Benjamin J.
通讯作者：
Cowling, Benjamin J.
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影响因子：
76.2
作者：
Zhu, Fengcai;Zhuang, Chunlan;Chu, Kai;Zhang, Liang;Zhao, Hui;Huang, Shoujie;Su, Yingying;Lin, Hongyan;Yang, Changlin;Jiang, Hanmin;Zang, Xia;Liu, Donglin;Pan, Hongxing;Hu, Yuemei;Liu, Xiaohui;Chen, Qi;Song, Qiaoqiao;Quan, Jiali;Huang, Zehong;Zhong, Guohua;Chen, Junyu;Han, Jinle;Sun, Hong;Cui, Lunbiao;Li, Jingxin;Chen, Yixin;Zhang, Tianying;Ye, Xiangzhong;Li, Changgui;Wu, Ting;Zhang, Jun;Xia, Ning-Shao
通讯作者：
Xia, Ning-Shao