Collagens as biomaterials
Collagens as biomaterials
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DOI：
10.1007/s10856-008-3415-4
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发表时间：
2009-12-01
影响因子：
3.7
通讯作者：
Werkmeister, Jerome A.
中科院分区：
文献类型：
--
作者：
Ramshaw, John A. M.;Peng, Yong Y.;Werkmeister, Jerome A.
本文综述了胶原蛋白作为生物材料的结构、功能及其应用。各种格式的胶原，无论是作为组织为基础的设备或作为重组的可溶性胶原进行了讨论。主要的重点是正在出现的新技术，这将导致新的和改进的基于胶原蛋白的医疗设备。特别是，重组胶原蛋白的发展，特别是利用微生物系统，使得开发安全和可再生的胶原蛋白产品成为可能。这些系统还允许开发新的非天然结构，例如含有关键功能域重复的胶原样结构或胶原结构域与另一种生物活性成分共价连接的嵌合结构。
This paper reviews the structure, function and applications of collagens as biomaterials. The various formats for collagens, either as tissue-based devices or as reconstituted soluble collagens are discussed. The major emphasis is on the new technologies that are emerging that will lead to new and improved collagen-based medical devices. In particular, the development of recombinant collagens, especially using microorganism systems, is allowing the development of safe and reproducible collagen products. These systems also allow for the development of novel, non-natural structures, for example collagen like structures containing repeats of key functional domains or as chimeric structures where a collagen domain is covalently linked to another biologically active component.