Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response.
Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response.
复制标题
受控释放抗炎药对宿主反应的细胞动力学的时空作用。
DOI：
10.1016/j.biomaterials.2011.02.048
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发表时间：
2011-07
期刊：
影响因子：
14
通讯作者：
Anderson DG
中科院分区：
文献类型：
--
作者：
Dang TT;Bratlie KM;Bogatyrev SR;Chen XY;Langer R;Anderson DG
一般来说，生物材料在植入体内时会引起非特异性的宿主反应。这种反应有可能干扰植入材料的功能。控制宿主反应的一种方法是局部、受控地释放抗炎剂。在这里，我们研究了抗炎药物对皮下植入聚(乳酸-羟基乙酸)微粒的天然免疫反应的细胞动力学的空间和时间效应。应用无创荧光成像技术研究地塞米松载药和释药动力学对局部和全身炎症细胞活性抑制的影响。对宿主反应的时间监测显示，在异物反应的早期阶段，炎性蛋白酶的抑制与异物反应的后期细胞渗透减少相关。我们相信，使用控释抗炎平台来调节早期的细胞动力学将有助于减少植入的生物材料和医疗器械的异物反应。
In general, biomaterials induce a non-specific host response when implanted in the body. This reaction has the potential to interfere with the function of the implanted materials. One method for controlling the host response is through local, controlled release of anti-inflammatory agents. Herein, we investigate the spatial and temporal effects of an anti-inflammatory drug on the cellular dynamics of the innate immune response to subcutaneously implanted poly(lactic-co-glycolic) microparticles. Noninvasive fluorescence imaging was used to investigate the influence of dexamethasone drug loading and release kinetics on the local and systemic inhibition of inflammatory cellular activities. Temporal monitoring of host response showed that inhibition of inflammatory proteases in the early phase was correlated with decreased cellular infiltration in the later phase of the foreign body response. We believe that using controlled-release anti-inflammatory platforms to modulate early cellular dynamics will be useful in reducing the foreign body response to implanted biomaterials and medical devices.