Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262
Dimeric hexylitaconic acids from the marine-derived fungusAspergillus welwitschiaeCUGBMF180262
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DOI：
10.1080/14786419.2020.1793152
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发表时间：
2020-07-14
影响因子：
2.2
通讯作者：
Xu, Xiuli
中科院分区：
文献类型：
--
作者：
Han, Jiahui;Yang, Na;Xu, Xiuli
在我们从海洋真菌中寻找新的次级代谢产物的过程中，发现了一种新的己基柠檬酸衍生物3-（5-甲氧羰基戊基）-4-甲基呋喃-2，5-二酮（1），和两种二聚体类似物asperwelwinates A和B（2和3），以及10种已知化合物，asperitidacidC（4），kotanin（5）和oranin（6），desertorin B（7），fonsecinone A（8），金曲霉酮A（9）、曲霉吡喃酮B和C（10和11）、曲霉黑素B（12）和焦酚（13）是从一株好维曲霉CUGBMF 180262中分离得到的。化合物1 - 3的结构通过高分辨质谱（HRMS）和一维/二维核磁共振（1D/2D NMR）的详细分析确定，化合物2和3的绝对构型通过电子圆二色谱（ECD）的计算和实验的比较确定。化合物8、9和11对幽门螺杆菌有一定的抑菌活性，最小抑菌浓度（MIC）为16 μ g/mL。
In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A and B (2and3), together with ten known compounds, asperitaconic acid C (4), kotanin (5) and orlandin (6), desertorin B (7), fonsecinone A (8), aurasperone A (9), asperpyrones B and C (10 and11), aspernigrin B (12), and pyrophen (13), were isolated from a strain ofAspergillus welwitschiaeCUGBMF180262. The structures of compounds1-3were determined by detailed analysis of HRMS, and 1D/2D NMR experiments, while the absolute configurations of2and3were determined by comparison of experimental and calculated electronic circular dichroism spectra.2and3were first reported dimeric hexylitaconic acid derivatives. Compounds8,9and11showed moderate antibacterial activities againstHelicobacter pyloriwith minimum inhibitory concentration (MIC) values of 16 mu g/mL.