Gap junctions mediate the spread of ischemia-reperfusion injury.
Gap junctions mediate the spread of ischemia-reperfusion injury.
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DOI：
10.1253/circj.cj-09-0342
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
T. Minamino
中科院分区：
文献类型：
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作者：
T. Minamino
缝隙连接是一组跨膜通道，通过连接相邻细胞的胞质区室形成直接细胞间通讯的管道。1缝隙连接细胞间通讯在组织稳态和生长、分化和发育的调节中起关键作用。在心脏中，缝隙连接介导心肌细胞之间的电耦合，形成细胞间通路，允许负责同步收缩的电兴奋波有序传播。因此，正常的心脏节律在很大程度上取决于心肌细胞通过缝隙连接的偶联。心律失常是许多类型心脏病的常见、严重且常常致命的并发症。虽然负责主动电位的膜特性的异常在心律失常的发生中起着核心作用，但有证据表明，间隙连接功能受损也有助于心律失常。因此，间隙连接功能异常对心肌电行为的影响已被广泛研究。相比之下，尽管已知间隙连接也允许小分子的扩散，但这种化学偶联的病理学意义相对较少引起关注。
ap junctions are clusters of transmembrane channels that form conduits for direct intercellular communication by linking the cytoplasmic compartments of neighboring cells.1 Gap junctional intercellular communications play a key role in tissue homeostasis and in the regulation of growth, differentiation, and development. In the heart, gap junctions mediate electrical coupling between cardiomyocytes, forming the intercellular pathways that allow orderly spread of the wave of electrical excitation responsible for synchronous contraction. Therefore, the normal cardiac rhythm largely depends on the coupling of cardiomyocytes by gap junctions. Disturbance of the cardiac rhythm is a common, serious, and often fatal complication of many types of heart disease. Although abnormalities of the membrane properties responsible for the active potential play a central role in the genesis of arrhythmia, evidence suggests that impaired gap junction function also contributes to cardiac arrhythmia. Therefore, the influence of abnormal gap junction function on myocardial electrical behavior has been extensively investigated. In contrast, although it is known that gap junctions also allow the diffusion of small molecules, the pathological significance of such chemical coupling has attracted relatively little attention.