Comorbidity of gout and rheumatoid arthritis in a large population database
Comorbidity of gout and rheumatoid arthritis in a large population database
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DOI：
10.1007/s10067-016-3477-5
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发表时间：
2017-03-01
影响因子：
3.4
通讯作者：
Amital, Howard
中科院分区：
文献类型：
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作者：
Merdler-Rabinowicz, Rona;Tiosano, Shmuel;Amital, Howard
风湿性关节炎和痛风的共存被认为是不寻常的。目前的研究是一项基于人群的横断面研究，利用以色列最大的医疗保健提供者组织Clalit Health Services的医学数据库。检索既往诊断为类风湿性关节炎的成人患者的数据。对于每名患者，随机选择5名年龄和性别匹配的对照患者。不同的参数，包括体重指数，社会经济地位，痛风的存在，以及吸烟和高血压进行了检查。该研究包括11，540名类风湿性关节炎患者和56，763名对照。研究组中痛风的比例高于对照组（1.61vs.0.92%，P <0. 001）。多因素分析显示，类风湿关节炎与痛风相关（OR = 1.72，95%CI 1.45-2.05，P = 0.00）。痛风在类风湿关节炎患者中的比例并不低于一般人群。
Coexistence of rheumatoid arthritis and gout is considered to be unusual. The current study was designed as a population-based cross-sectional study, utilizing the medical database of Clalit Health Services, the largest healthcare provider organization in Israel. Data of adult patients who were previously diagnosed with rheumatoid arthritis was retrieved. For each patient, five age- and sex-matched control patients were randomly selected. Different parameters including BMI, socioeconomic status, and existence of gout as well as smoking and hypertension were examined for both groups. The study included 11,540 patients with rheumatoid arthritis and 56,763 controls. The proportion of gout in the study group was high compared to controls (1.61 vs. 0.92%, P < 0.001). In a multivariate analysis, rheumatoid arthritis was associated with gout (OR = 1.72, 95% CI 1.45-2.05, P = 0.00). The proportion of gout in rheumatoid arthritis patients is not lower than in the general population.