Postmortem redistribution of methamphetamine and amphetamine in blood specimens from various blood vessels and in the specimens from pericardial fluid, bile, stomach contents and various solid tissues collected from a human cadaver
Postmortem redistribution of methamphetamine and amphetamine in blood specimens from various blood vessels and in the specimens from pericardial fluid, bile, stomach contents and various solid tissues collected from a human cadaver
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死后各种血管的血液样本以及从人类尸体收集的心包液、胆汁、胃内容物和各种固体组织的样本中甲基苯丙胺和苯丙胺的重新分布
作者：
Amin Wurita;Koutaro Hasegawa;K. Minakata;K. Gonmori;H. Nozawa;I. Yamagishi;O. Suzuki;Kanako Watanabe
我们最近遇到一起涉及甲基苯丙胺（MA）的尸检案件。尸检间隔估计长达 6 至 7 天。我们采集了心脏和血管9个部位的血液标本，以及心包液、胆汁、胃内容物和9个实体组织的标本（共21份标本），采用改良的QuEChERS提取后，采用液相色谱-串联质谱法对MA和代谢物安非他明进行分析。胃内容物中 MA 浓度最高，表明 MA 是口服摄入的。在血液样本中，MA 浓度范围为 268 至 911 ng/mL。左心血中MA的浓度高于右心血中的MA浓度。尽管如此，肺静脉中的MA浓度远低于左心血中的MA浓度。静脉血管中MA浓度的比较表明，腔静脉中MA浓度最高，其次是髂静脉，股静脉中最低，这表明在死后间隔期间，MA浓度通过穿过静脉血管薄壁的扩散而降低。应考虑通过股静脉薄壁扩散造成的外源性部分损失，尤其是当死后间隔相对较长时。
We recently encountered an autopsy case in which methamphetamine (MA) was involved. The postmortem interval was estimated to be as long as 6–7 days. We collected the blood specimens from 9 locations of the heart and blood vessels, and specimens from pericardial fluid, bile, stomach contents and 9 solid tissues (in total 21 specimens), which were subjected to analysis of MA and the metabolite amphetamine by liquid chromatography–tandem mass spectrometry after a modified QuEChERS extraction. The highest concentration of MA was found for the stomach contents, suggesting the oral ingestion of MA. Among the blood specimens, their MA concentrations varied from 268 to 911 ng/mL. The concentration of MA in the left heart blood was higher than that in the right heart blood. In spite of this, the MA concentration in the pulmonary vein was much lower than that in the left heart blood. The comparison of MA concentrations in venous blood vessels showed that MA concentration was highest in the vena cava, followed by the iliac vein, and was lowest in the femoral vein, suggesting that MA concentration is decreased by diffusion across the thin walls of venous blood vessels during the postmortem interval. The partial loss of a xenobiotic by diffusion via the thin wall of the femoral vein should be taken into consideration especially when the postmortem interval is relatively long.