Neuropeptides and ATP signaling in the trigeminal ganglion.
Neuropeptides and ATP signaling in the trigeminal ganglion.
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DOI：
10.1016/j.jdsr.2017.01.003
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Yamanaka A
中科院分区：
文献类型：
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作者：
Goto T;Iwai H;Kuramoto E;Yamanaka A
来自口面部结构的外周伤害性刺激主要由三叉神经传递。三叉神经节神经元根据周围伤害性刺激产生P物质、降钙素基因相关肽等神经肽，三叉神经节内除产生神经肽外，还存在独特的非突触相互作用系统。三叉神经节内的神经元被卫星胶质细胞(SGCs)包围，这些细胞最初接受来自三叉神经节神经元的信号。这些被激活的SGCs分泌一个递质来激活相邻的SGCs或TG神经元，从而放大信号，例如，从下颌神经元到TG中的上颌神经元。与背根神经节类似，在三叉神经节，小胶质细胞/巨噬细胞样细胞(MLCs)通过摄取来自TG神经元或SGCs的递质而被激活。神经元、SGCs和MLCs之间的这种交流会导致异位疼痛、感觉过敏或痛觉过敏等反应。本文的重点是上颌神经和下颌神经在三叉神经节中通过神经肽的协同作用，以及神经元向SGCs和MLCs传递的腺苷3‘-磷酸(ATP)信号。受刺激的神经元或通过囊泡核苷酸转运体分泌三磷酸腺苷，或从神经元胞体分泌神经肽来介导信号传递。
Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons. These activated SGCs secrete a transmitter to activate adjacent SGCs or TG neurons, thereby amplifying the signal, for example, from mandibular neurons to maxillary neurons in the TG. Similar to the dorsal root ganglion, in the TG, microglia/macrophage-like cells (MLCs) are activated by uptake of a transmitter from TG neurons or SGCs. This communication between neurons, SGCs, and MLCs results in responses such as ectopic pain, hyperesthesia, or allodynia. The focus of this review is the cooperative interaction of the maxillary and mandibular nerves in the TG by neuropeptides, and adenosine 3′-phosphate (ATP) signaling from neurons to SGCs and MLCs. Stimulated neurons either secrete ATP by means of vesicular nucleotide transporters, or secrete neuropeptides from the neuronal cell body to mediate signal transmission.